Evidence map›Paper›PMID 40507917›Full record

ArticleInternational journal of molecular sciences2025

Circulating N-Acetylaspartate Levels Associate with Measures of Peripheral and Tissue-Specific Insulin Sensitivity.

Eleni Rebelos, Miikka-Juhani Honka, Aino Latva-Rasku, Johan Rajander, Paulina Salminen, Ioanna A Anastasiou, Dimitris Kounatidis, Nikolaos Tentolouris, Beatrice Campi, Angela Dardano and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Emerging Role of N-Acetylaspartate in Cancer.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eleni RebelosTurku PET Centre, University of Turku, 20014 Turku, Finland.
Miikka-Juhani HonkaTurku PET Centre, University of Turku, 20014 Turku, Finland.ORCID 0000-0001-9875-5863
Aino Latva-RaskuTurku PET Centre, University of Turku, 20014 Turku, Finland.ORCID 0000-0001-8786-9160
Johan RajanderTurku PET Centre, Accelerator Laboratory, Åbo Akademi University, 20520 Turku, Finland.
Paulina SalminenDivision of Digestive Surgery and Urology, Turku University Hospital, 20520 Turku, Finland.ORCID 0000-0001-6435-9264
Ioanna A AnastasiouDiabetes Center, First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.ORCID 0000-0002-7560-0575
Dimitris KounatidisDiabetes Center, First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.ORCID 0000-0003-4338-4879
Nikolaos TentolourisDiabetes Center, First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.ORCID 0000-0003-0615-2534
Beatrice CampiConsiglio Nazionale delle Ricerche (CNR), Institute of Clinical Physiology, 56124 Pisa, Italy.ORCID 0000-0002-0448-4124
Angela DardanoDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Giuseppe DanieleDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Alessandro SabaLaboratory of Clinical Pathology, St. Chiara University Hospital, 56100 Pisa, Italy.ORCID 0000-0003-0611-5549
Ele FerranniniConsiglio Nazionale delle Ricerche (CNR), Institute of Clinical Physiology, 56124 Pisa, Italy.
Pirjo NuutilaTurku PET Centre, University of Turku, 20014 Turku, Finland.ORCID 0000-0001-9597-338X

Funding

Academy of Finland 332151European Foundation for the Study of Diabetes 96402
6 · The paper itself

Abstract

N-acetylaspartate (NAA) is the second most abundant metabolite in the human brain. Quantifiable amounts of NAA are also present in the blood, but its role in the peripheral tissues is largely unknown. First, we determined the acute effects of insulin administration on NAA concentrations; second, we assessed whether circulating NAA levels associate with markers of central and peripheral insulin sensitivity. A total of 24 persons living with obesity and 19 healthy, lean controls, without neurological disorders, underwent a euglycemic hyperinsulinemic clamp combined with fluorodeoxyglucose positron emission tomography ([

Indexed as

Aspartic AcidInsulin ResistanceObesityAdultBiomarkersFemaleGlucose Clamp TechniqueHumansInsulinMaleMiddle AgedPositron-Emission TomographyAspartic AcidBiomarkersInsulinN-acetylaspartateeuglycemic hyperinsulinemic clampinsulin sensitivityN-acetylaspartatepositron emission tomography

Identifiers

PMID40507917
PMCPMC12154542

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.