Evidence map›Paper›PMID 40508150›Full record

ArticleInternational journal of molecular sciences2025

Influence of HLA Class I and II Polymorphisms on COVID-19 Severity in a South Brazilian Population.

Sergio Grava, Matheus Braga, Victor Hugo de Souza, Afonso Carrasco Pepineli, Aléia Harumi Uchibaba Yamanaka, Christiane Maria Ayo, Joana Maira Valentini Zacarias, Andréa Name Colado Simão, Larissa Danielle Bahls Pinto, Quirino Alves de Lima Neto and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sergio GravaPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0009-0001-6532-3383
Matheus BragaPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-6316-4200
Victor Hugo de SouzaPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-6620-540X
Afonso Carrasco PepineliPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0009-0002-0711-4505
Aléia Harumi Uchibaba YamanakaPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.
Christiane Maria AyoLaboratory of Immunogenetics, Department of Dermatological, Infectious and Parasitic Diseases, Faculty of Medicine of São José do Rio Preto, São José do Rio Preto 15090-000, SP, Brazil.
Joana Maira Valentini ZacariasPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-5519-715X
Andréa Name Colado SimãoDepartment of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Londrina 86038-350, PR, Brazil.
Larissa Danielle Bahls PintoPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0001-6469-3123
Quirino Alves de Lima NetoPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.
Jeane Eliete Laguila VisentainerPost-Graduation Program in Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá 87020-900, PR, Brazil.ORCID 0000-0002-5815-7903

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high variability of human leukocyte antigen (

Indexed as

COVID-19Histocompatibility Antigens Class IHLA-DRB1 ChainsPolymorphism, GeneticAdultAgedAllelesBrazilCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedSARS-CoV-2Severity of Illness IndexHistocompatibility Antigens Class IHLA-DRB1 Chainscoronavirusgenetichistocompatibility antigen classesHLA-DR beta-chainsin silico modelpolymorphism

Identifiers

PMID40508150
PMCPMC12154496

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.