Evidence map›Paper›PMID 40508182›Full record

ReviewInternational journal of molecular sciences2025

Advances in Molecular Imaging of VEGFRs: Innovations in Imaging and Therapeutics.

Hanieh Karimi, Sarah Lee, Wenqi Xu, Sigrid A Langhans, David K Johnson, Erik Stauff, Heidi H Kecskemethy, Lauren W Averill, Xuyi Yue

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Enhanced Tumor-to-Background Contrast with [Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanieh KarimiDepartment of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.
Sarah LeeDepartment of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.
Wenqi XuDepartment of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.ORCID 0009-0007-7192-4656
Sigrid A LanghansDiagnostic & Research PET/MR Center, Nemours Children's Health, Delaware, Wilmington, DE 19803, USA.ORCID 0000-0003-4695-7468
David K JohnsonComputational Chemical Biology Core, University of Kansas, Lawrence, KS 66047, USA.
Erik StauffDepartment of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.
Heidi H KecskemethyDepartment of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.
Lauren W AverillDepartment of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.
Xuyi YueDepartment of Radiology, Diagnostic and Research PET/MR Center, Nemours Children's Health, Wilmington, DE 19803, USA.ORCID 0000-0002-3783-6392

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
Development and Evaluation of Radiotracers for PET Imaging Angiotensin-Converting Enzyme 2 (ACE2)R21EB032025 · NIBIB · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI YUE, XUYI · 2021 to 2023
$568k
NIBIB NIH HHS R21 EB032025NIGMS NIH HHS P20 GM103446NIH HHS P20GM103446; EB032025; P20GM103446-23S6The Nemours Foundation N/A
6 · The paper itself

Abstract

Vascular endothelial growth factor receptors (VEGFRs) are key regulators of angiogenesis, lymphangiogenesis, and vascular permeability, playing essential roles in both physiological and pathological processes. The VEGFR family, including VEGFR-1, VEGFR-2, and VEGFR-3, interacts with structurally related VEGF ligands (VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor [PlGF]), activating downstream signaling pathways that mediate critical cellular processes, including proliferation, migration, and survival. Dysregulation of VEGFR signaling has been implicated in numerous diseases, such as cancer, cardiovascular conditions, and inflammatory disorders. Targeting VEGFRs with radiopharmaceuticals, such as radiolabeled peptides, antibodies, and specific tracers like

Indexed as

Molecular ImagingReceptors, Vascular Endothelial Growth FactorAnimalsHumansNeoplasmsNeovascularization, PathologicPositron-Emission TomographyRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonRadiopharmaceuticalsReceptors, Vascular Endothelial Growth Factorangiogenesislymphangiogenesisnuclear medicine imagingradiopharmaceuticalstargeted therapyVEGFRs

Identifiers

PMID40508182
PMCPMC12155355

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.