Evidence mapPaperPMID 40508808Full record

ReviewPolymers2025

A State-of-the-Art Review on Recent Biomedical Application of Polysaccharide-Based Niosomes as Drug Delivery Systems.

Andreea-Teodora Iacob, Andra Ababei-Bobu, Oana-Maria Chirliu, Florentina Geanina Lupascu, Ioana-Mirela Vasincu, Maria Apotrosoaei, Bianca-Stefania Profire, Georgiana-Roxana Tauser, Dan Lupascu, Lenuta Profire

Abstract readReview
In one paragraph

Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreea-Teodora IacobDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0003-2530-3801
Andra Ababei-BobuDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0009-0005-6593-7691
Oana-Maria ChirliuDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0002-0667-1484
Florentina Geanina LupascuDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.
Ioana-Mirela VasincuDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0002-0873-2789
Maria ApotrosoaeiDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.
Bianca-Stefania ProfireDepartment of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0003-1792-7139
Georgiana-Roxana TauserDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0002-8965-4208
Dan LupascuDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0002-3007-7311
Lenuta ProfireDepartment of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0002-7953-3023

Funding

L'Oréal Romania FWIS, Romania National Program for Woman in Science 2023, area Life of Science National Program for Woman in Science 2023
6 · The paper itself

Abstract

The development of nanocarriers for drug delivery has drawn a lot of attention due to the possibility for tailored delivery to the ill region while preserving the neighboring healthy tissue. In medicine, delivering drugs safely and effectively has never been easy; therefore, the creation of surfactant-based vesicles (niosomes) to enhance medication delivery has gained attention in the past years. Niosomes (NIOs) are versatile drug delivery systems that facilitate applications varying from transdermal transport to targeted brain delivery. These self-assembling vesicular nano-carriers are formed by hydrating cholesterol, non-ionic surfactants, and other amphiphilic substances. The focus of the review is to report on the latest NIO-type formulations which also include biopolymers from the polysaccharide class, highlighting their role in the development of these drug delivery systems (DDSs). The NIO and polysaccharide types, together with the recent pharmaceutical applications such as ocular, oral, nose-to brain, pulmonary, cardiac, and transdermal drug delivery, are all thoroughly summarized in this review, which offers a comprehensive compendium of polysaccharide-based niosomal research to date. Lastly, this delivery system's limits and prospects are also examined.

Indexed as

drug delivery systemsmedical and pharmaceutical applicationsniosomes (NIOs)polysaccharide

Identifiers

PMID40508808
PMCPMC12158076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.