The Effect of Quercetin Loading in Polylactic Acid-Based Electrospun Fibers on Their Antioxidant, Antibacterial and Antitumor Properties.

Nikoleta Stoyanova, Tsvetozara Damyanova, Tsvetelina Paunova-Krasteva, Ani Georgieva, Reneta Toshkova, Mariya Spasova

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Quercetin and Rosmarinic Acid Functionalized Hybrid Electrospun Nanofibers with Strong Antioxidant and Anticancer Activities.Biomimetics (Basel, Switzerland) · 2026
Article
Fabrication and Detailed Characterization of PLA/PEG Composite Nanofibers for the Co-Delivery and Synergistic Release of Quercetin and Rosmarinic Acid via Electrospinning.Molecules (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nikoleta StoyanovaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 103A, 1113 Sofia, Bulgaria.ORCID 0000-0001-5821-3509

Tsvetozara DamyanovaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria.ORCID 0009-0003-2783-6342

Tsvetelina Paunova-KrastevaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria.ORCID 0000-0002-8376-8917

Ani GeorgievaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria.ORCID 0000-0001-9238-6243

Reneta ToshkovaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 25, 1113 Sofia, Bulgaria.

Mariya SpasovaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 103A, 1113 Sofia, Bulgaria.ORCID 0000-0002-1603-4294

Funding

Operational Program "Research, Innovation and Digitalization for Smart Transformation", PRIDST 2021-2027, funded by EU and Bulgarian Government Project Centre of Competence "Sustainable Utilization of Bio Resources and Waste of Medicinal and Aromatic Plants for Innovative Bioactive Products").

6 · The paper itself

Abstract

Quercetin (QUE) is a bioactive flavonoid that is naturally present in various fruits and possesses many pharmacological activities. Despite its health benefits, the bioavailability of quercetin is relatively low due to its crystalline form and hydrophobic structure. An approach to overcoming these drawbacks is its incorporation into amorphous polymer matrices. PLA and PLA/PEG fibrous materials loaded with QUE were obtained by electrospinning. The XRD analysis revealed a visible decrease in the crystallinity of QUE after its incorporation into PLA and PLA/PEG fibers. The obtained fibrous materials and, especially, the PLA/PEG mat loaded with the flavonoid exhibited high antioxidant activity due to the better wettability and higher release rate of the bioactive compound. Moreover, the PLA/QUE and PLA/PEG/QUE mats possessed antibacterial properties against

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsAntioxidantsPolyestersQuercetinCell Line, TumorHumansMicrobial Sensitivity TestsNanofibersPolyethylene GlycolsPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsAntineoplastic AgentsAntioxidantsPolyestersPolyethylene Glycolspoly(lactide)Quercetinantibacterial and antitumor propertiesantioxidantelectrospinningpolylactic acidquercetinwater-soluble polymer

Identifiers

PMID40509197

DOI10.3390/molecules30112307

PMCPMC12155772

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.