Evidence map›Paper›PMID 40509253›Full record

ArticleMolecules (Basel, Switzerland)2025

The Synthesis and Biological Evaluation of a Novel Pleuromutilin Derivative Containing a 4-Fluorophenyl Group Targeting MRSA.

Yongfei Wang, Yi Zhao, Haiting Wang, Bo Liu, Shuangyi Zhang, Yuan Liu, Ruinan Li, Tao Zhang, Surong Hasi, Wei Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yongfei WangLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.
Yi ZhaoLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.ORCID 0009-0008-2950-230X
Haiting WangShandong Provincial Animal and Poultry Green Health Products Creation Engineering Laboratory, Institute of Poultry Science, Shandong Academy of Agricultural Science, Jinan 250100, China.
Bo LiuLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.
Shuangyi ZhangLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.
Yuan LiuLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.
Ruinan LiLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.
Tao ZhangLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.
Surong HasiLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.
Wei MaoLaboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, No. 29, Erdosdong Road, Hohhot 010011, China.

Funding

Inner Mongolia Agricultural University young teachers research ability promotion project grant number BR220111Inner Mongolia Autonomous Region University youth Science and Technology talentsInner Mongolia Autonomous Region Department of Education first-class scientific research pro-ject grant number YLXKZX-NND-012Science and Technology Program of the Inner Mongolia Autonomous Region 2020GG0042the Inner Mongolia Medical University Youth Project YKD2022QN036the Inner Mongolia Natural Science Foundation project grant number 2022MS03048, 2023LHMS03015
6 · The paper itself

Abstract

The pleuromutilin derivative, the compound PL-W, was synthesized by introducing a 4-fluorophenyl group at the C21 position and selected for comprehensive antibacterial evaluation. PL-W demonstrated notable antibacterial activity against methicillin-resistant

Indexed as

Anti-Bacterial AgentsDiterpenesMethicillin-Resistant Staphylococcus aureusPolycyclic CompoundsAnimalsBiofilmsDisease Models, AnimalHumansMiceMicrobial Sensitivity TestsMolecular Docking SimulationPleuromutilinsStaphylococcal InfectionsAnti-Bacterial AgentsDiterpenesPleuromutilinsPolycyclic Compoundsantibacterial activitymethicillin-resistant Staphylococcus aureusmolecular dockingpleuromutilin derivative

Identifiers

PMID40509253
PMCPMC12156078

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.