Gating Mechanism for Biased Agonism at Angiotensin II Type 1 Receptors.

Graham J Moore, Harry Ridgway, Laura Kate Gadanec, Vasso Apostolopoulos, Anthony Zulli, John M Matsoukas

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Graham J MoorePepmetics Inc., 772 Murphy Place, Victoria, BC V6Y 3H4, Canada.

Harry RidgwayTHERAmolecular, LLC, Rodeo, NM 88056, USA.

Laura Kate GadanecInstitute for Health and Sport, Immunology and Translational Research Group, Victoria University, Werribee, VIC 3030, Australia.ORCID 0000-0002-4801-8061

Vasso ApostolopoulosSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC 3000, Australia.ORCID 0000-0001-6788-2771

Anthony ZulliInstitute for Health and Sport, Immunology and Translational Research Group, Victoria University, Werribee, VIC 3030, Australia.

John M MatsoukasInstitute for Health and Sport, Immunology and Translational Research Group, Victoria University, Werribee, VIC 3030, Australia.ORCID 0000-0001-5554-2964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the interaction of angiotensin II (AngII) with AngII type 1 receptors (AT

Indexed as

Angiotensin IIReceptor, Angiotensin, Type 1AnimalsHumansProtein BindingSignal TransductionAngiotensin IIReceptor, Angiotensin, Type 1angiotensin IIangiotensin II type 1 receptorcharge relay systemsteered molecular dynamics

Identifiers

PMID40509287

DOI10.3390/molecules30112399

PMCPMC12156802

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.