Evidence map›Paper›PMID 40509339›Full record

ArticleMolecules (Basel, Switzerland)2025

Isomeric 3-Pyridinylmethylcoumarins Differ in Erk1/2-Inhibition and Modulation of BV2 Microglia-Mediated Neuroinflammation.

Rami Schulzki, Matthias Apweiler, Caroline Röttger, Christoph W Grathwol, Nora Struchtrup, Sophia Abou El Mirate, Claus Normann, Stefan Bräse, Bernd L Fiebich

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rami SchulzkiNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.
Matthias ApweilerNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.
Caroline RöttgerInstitute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, D-76131 Karlsruhe, Germany.ORCID 0009-0007-6906-2532
Christoph W GrathwolInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, D-76131 Karlsruhe, Germany.ORCID 0000-0003-0232-3279
Nora StruchtrupInstitute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, D-76131 Karlsruhe, Germany.ORCID 0009-0004-8480-6710
Sophia Abou El MirateInstitute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, D-76131 Karlsruhe, Germany.
Claus NormannMechanisms of Depression Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.
Stefan BräseInstitute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, D-76131 Karlsruhe, Germany.ORCID 0000-0003-4845-3191
Bernd L FiebichNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany.ORCID 0000-0002-9261-6771

Funding

Baden-Wuerttemberg Ministry of Science, Research and Art and the University of Freiburg Library Open Access PublishingDeutsche Forschungsgemeinschaft 266379491Deutsche Forschungsgemeinschaft 284178167Jürgen Manchot Foundation X
6 · The paper itself

Abstract

Coumarins are known for their multiple biological effects and have been established as anti-coagulative drugs for years. Furthermore, some coumarins can promote anti-inflammatory effects via the GPR55 receptor, and dual target coumarins have been synthesized. Anti-inflammatory drugs might be beneficial in the treatment of neuropsychiatric disorders, as the inflammatory hypothesis suggests. For the current study, we compared isomeric 3-pyridinylmethylcoumarins with altered N-atom position regarding their effects on cytokine and chemokine synthesis and expression in LPS-stimulated BV2 microglial cells. The 3-pyridin-4-yl-methylcoumarin showed the most potent anti-inflammatory effects, followed by the 3-pyridin-2-ylmethylcoumarin analog. The observed effects might be mediated by an inhibition of ERK phosphorylation.

Indexed as

Anti-Inflammatory AgentsCoumarinsMAP Kinase Signaling SystemMicrogliaMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Neuroinflammatory DiseasesAnimalsCell LineCytokinesLipopolysaccharidesMicePhosphorylationAnti-Inflammatory AgentsCoumarinsCytokinesLipopolysaccharidesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3chemokinescoumarinscytokinesErk1/2GPR55isomericMAPKmicroglianeuroinflammation

Identifiers

PMID40509339
PMCPMC12156390

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.