Evidence map›Paper›PMID 40509746›Full record

ArticleMolecular pain

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank (

Qi Pan, Tengda Cai, Yiwen Tao, Luning Yang, Roger Compte, Maryam Kazemi Naeini, Mainul Haque, Tania Dottorini, Frances Mk Williams, Weihua Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qi PanNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China.ORCID 0000-0003-0135-9122
Tengda CaiNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China.
Yiwen TaoNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China.
Luning YangNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China.
Roger CompteDepartment Twin Research and Genetic Epidemiology, School of Life Course Science, King's College London, London, England, UK.
Maryam Kazemi NaeiniDepartment Twin Research and Genetic Epidemiology, School of Life Course Science, King's College London, London, England, UK.
Mainul HaqueSchool of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, Zhejiang, China.
Tania DottoriniSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
Frances Mk WilliamsDepartment Twin Research and Genetic Epidemiology, School of Life Course Science, King's College London, London, England, UK.
Weihua MengNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China.ORCID 0000-0001-5388-8494

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectivesWidespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic variants associated with widespread pain by utilizing the extensive UK Biobank dataset.

methodsWe conducted a primary genome-wide association study (GWAS) using a novel definition of widespread pain, defined as pain experienced all over the body during the past month. Sex-stratified GWAS analysis approach was also performed to analyze the impact of sex on widespread pain.

resultsThe primary GWAS identified one novel significant genetic locus (rs34691025,

conclusionsOur study advances the understanding of the genetic factors contributing to widespread pain, highlighting notable differences between males and females and identifying a novel genetic locus associated with this condition.

Indexed as

Biological Specimen BanksGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyPainAgedFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideUK BiobankUnited Kingdomgenetic correlationsgenome-wide association studyMendelian randomizationphenome-wide association studyUK BiobankWidespread pain

Identifiers

PMID40509746
PMCPMC12166267

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.