Evidence map›Paper›PMID 40509809›Full record

ArticleJournal of chemical information and modeling2025

The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrP

Xiaohan Zhang, Huan Xu, Huayuan Tang, Zhongyue Lv, Yu Zou, Fengjuan Huang, Feng Ding, Yunxiang Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaohan ZhangSchool of Physical Science and Technology, Ningbo University, Ningbo 315211, China.
Huan XuSchool of Physical Science and Technology, Ningbo University, Ningbo 315211, China.
Huayuan TangDepartment of Engineering Mechanics, Hohai University, Nanjing 211100, China.
Zhongyue LvNingbo Institute of Innovation for Combined Medicine and Engineering, The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo 315211, China.
Yu ZouDepartment of Sport and Exercise Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-5699-5869
Fengjuan HuangNingbo Institute of Innovation for Combined Medicine and Engineering, The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo 315211, China.
Feng DingDepartment of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States.ORCID 0000-0003-1850-6336
Yunxiang SunSchool of Physical Science and Technology, Ningbo University, Ningbo 315211, China.ORCID 0000-0001-9799-7131

Funding

Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Jeryl Jones · 2018 to 2026
$24.7M
Inhibition of Human Islet Amyloid Polypeptide AggregationR35GM145409 · NIGMS · CLEMSON UNIVERSITY · PI Feng Ding · 2022 to 2026
$2.0M
NIGMS NIH HHS P20 GM121342NIGMS NIH HHS R35 GM145409
6 · The paper itself

Abstract

The abnormal aggregation of human prion protein (hPrP) into cross-β fibrillar amyloid deposits is associated with prion diseases such as Creutzfeldt-Jakob disease and fatal familial insomnia. However, the molecular mechanisms underlying the early stages of prion aggregation remain poorly understood. In this study, we employed multiple long-time scale atomistic discrete molecular dynamics (DMD) simulations to investigate the conformational dynamics of hPrP

Indexed as

GlycinePrion ProteinsProtein AggregatesAmino Acid SequenceHumansMolecular Dynamics SimulationProtein Conformation, beta-StrandProtein MultimerizationGlycinePrion ProteinsProtein Aggregates

Identifiers

PMID40509809
PMCPMC12227174

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.