Evidence map›Paper›PMID 40509821›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2025

[Identifying genetic etiology of ischemic stroke based on pleiotropy of obesity related genes: A sibling study].

K Wang, H Wang, H Yu, R Yang, L Zheng, J Wu, X Qin, T Wu, D Chen, Y Wu and 1 more

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

K WangDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
H WangDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
H YuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
R YangDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
L ZhengDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
J WuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
X QinDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
T WuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
D ChenDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
Y WuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
Y HuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify genetic etiology of ischemic stroke (IS) based on pleiotropy of obesity related genes.

methodsA discordant sib-pair study was designed based on the Fangshan family cohort in Beijing. Body mass index (BMI) polygenic risk score (PRS) was first constructed under different

resultsA total of 541 participants were enrolled, with an average age of (58.4±8.1) years, including 326 discordant sib pairs of ischemic stroke. Compared with non-IS participants, IS participants with males, education level below junior high school, hypertension and hyperlipidemia accounted for a higher proportion (

conclusionPleiotropy between BMI-related genes and IS was observed. Forty-five SNPs were found with linkage and association with IS in the pleiotropy gene set and mapped to 40 genes, which were functionally enriched in lipid metabolic pathways. The rs2232852 corrected by multiple tests during association analysis validation was mapped to

Indexed as

Genetic PleiotropyGenetic Predisposition to DiseaseIschemic StrokeObesityAgedBody Mass IndexFemaleHumansLinkage DisequilibriumMaleMiddle AgedMultifactorial InheritancePolymorphism, Single NucleotideRisk FactorsSiblingsBody mass indexGenetic association studiesIschemic strokePleiotropySiblings

Identifiers

PMID40509821
PMCPMC12171603

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.