ReviewNucleus (Austin, Tex.)2025
Unraveling gene expression: a beginner's guide from chromatin modifications to mRNA export in
Review in Nucleus (Austin, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sus1 Modulates Chromatin Remodeling and Gene Expression via the Cell Wall Integrity Pathway in Saccharomyces cerevisiae.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding gene expression requires grasping its multi-step processes, from chromatin remodeling to mRNA export. This manuscript provides an accessible entry point for PhD students and junior postdocs beginning research in this area, using yeast as a model organism. We present a beginner-friendly overview of gene expression, emphasizing the dynamic interplay between chromatin modifications, transcription, mRNA processing, and export. Key topics include chromatin organization, with a focus on H2B ubiquitylation and H3 methylation crosstalk; transcriptional control by RNA polymerase II, including initiation, elongation, and termination; and the export of mRNAs via Mex67-Mtr2, adaptor proteins, and the TREX and TREX-2 complexes at the nuclear pore complex. Relevant examples from yeast genetics, biochemistry, and structural biology illustrate each step. This overview aims to equip new researchers with foundational knowledge and provides references to key studies, current challenges, and open questions in the regulation of gene expression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.