Evidence map›Paper›PMID 40509901›Full record

ArticleActa biochimica et biophysica Sinica2025

Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease.

Jiaqi Chen, Shuting Zhang, Xiaoquan Xue, Xiaoqin Ma, Aomiao Chen, Yichuan Wu, Geningyue Wang, Qian Zhang, Yaoming Xue, Yijie Jia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiaqi ChenDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Shuting ZhangDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Xiaoquan XueDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Xiaoqin MaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Aomiao ChenDe Feng Academy, Southern Medical University, Guangzhou 510515, China.
Yichuan WuDe Feng Academy, Southern Medical University, Guangzhou 510515, China.
Geningyue WangDe Feng Academy, Southern Medical University, Guangzhou 510515, China.
Qian ZhangDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yaoming XueDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yijie JiaDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zongji ZhengDepartment of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteinuria-induced damage to renal tubular epithelial cells is one of the main causes of diabetic kidney disease (DKD), and the clearance of overloaded albumin by lysosomes is crucial for maintaining the homeostasis of renal tubular epithelial cells. Therefore, lysosomal damage is closely related to the pathogenesis of DKD, but effective prevention and treatment measures are still lacking. Melatonin (MLT) is secreted by the pineal gland and can not only regulate circadian rhythms but also maintain lysosomal homeostasis. In this study, we demonstrate the presence of significant lysosomal damage in the renal tubules of DKD patients, which causes autophagy impairment and a concomitant oxidative stress imbalance; however, MLT can upregulate transcription factor EB (TFEB) to improve lysosomal damage and restore the biosynthesis of this organelle. Mechanistically, MLT may protect lysosomes via the upregulation of TFEB and the miR-205-5p-LRP-1 pathway in renal tubules, thus improving autophagy dysfunction and oxidative imbalance in DKD.

Indexed as

Diabetic NephropathiesLysosomesMelatoninAnimalsAutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsFemaleHumansKidney TubulesMaleMicroRNAsMiddle AgedOxidative StressBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMelatoninMicroRNAsTFEB protein, humandiabetic kidney diseaselysosomemelatoninTFEBtubular epithelial cell

Identifiers

PMID40509901
PMCPMC12616729

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.