Evidence map›Paper›PMID 40509977›Full record

ArticleChemPlusChem2025

Synthesis of New N,N'-Diarylureas and Their Theoretical Study as Cannabinoid-1 Receptor Inhibitors.

Eirini Tsemperlidou, Nikitas Georgiou, Demeter Tzeli, Nikolaos Karousis, George Varvounis

Abstract read
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In one paragraph

Article in ChemPlusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eirini TsemperlidouLaboratory of Organic Chemistry, Department of Chemistry, University of Ioannina, Ioannina, 45110, Greece.
Nikitas GeorgiouLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, 15784, Greece.
Demeter TzeliLaboratory of Physical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, 15784, Greece.
Nikolaos KarousisLaboratory of Organic Chemistry, Department of Chemistry, University of Ioannina, Ioannina, 45110, Greece.ORCID 0000-0002-1480-8380
George VarvounisLaboratory of Organic Chemistry, Department of Chemistry, University of Ioannina, Ioannina, 45110, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of new N,N'-diarylureas is reported as potential cannabinoid-1 (CB-1) receptor inhibitors. The synthesis of the new N,N'-diarylureas is achieved from the reaction of two substituted anilines with the aid of triphosgene. One aniline carries a pyrazol-1-yl or 1H-1,2,3-triazolyl or 2H-1,2,3-triazolyl propan-2-one group at position-3, while the other aniline is substituted by fluoro, bromo, methoxy, cyano, morpholino, or 4-methyl-2-nitro groups. All new compounds are investigated through density functional theory calculations, molecular docking, and molecular dynamics simulations, showing a strong ability to bind to the orthosteric pocket of the CB-1 receptor and to the allosteric position when CB1 is in complex with agonist AM841. The binding is comparable to that of the well-known CB-1 inhibitor PSNBAM-1. Especially, 1-{3-[2-(1H-pyrazol-1-yl)acetyl]phenyl}-3-(4-methyl-3-nitrophenyl)urea presents better theoretical results than PSNBAM-1.

Indexed as

Receptor, Cannabinoid, CB1UreaDensity Functional TheoryHumansMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructurePyrazolesPyrazolesReceptor, Cannabinoid, CB1Ureacannabinoid receptorsdensity functional theorymolecular dockingmolecular dynamicspyrazolo‐based diaryl ureastriazolo‐based diaryl ureas

Identifiers

PMID40509977
PMCPMC12352735

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.