Evidence map›Paper›PMID 40510178›Full record

ArticleBrain, behavior, & immunity - health2025

Altered behaviour and immune response in mice with NHLRC2 p.Asp148Tyr variant.

Anniina E Hiltunen, Salla M Kangas, Aishwarya Gondane, Henna Koivisto, Kari Salokas, Anne Heikkinen, Miia H Salo, Tapio Röning, Antti Tallgren, Virpi Glumoff and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Anniina E HiltunenMedical Research Center Oulu and Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Salla M KangasMedical Research Center Oulu and Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Aishwarya GondaneDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Henna KoivistoA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Kari SalokasInstitute of Biotechnology, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Anne HeikkinenBiocenter Oulu, University of Oulu, Oulu, Finland.
Miia H SaloMedical Research Center Oulu and Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Tapio RöningECM-Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Antti TallgrenMedical Research Center Oulu and Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Virpi GlumoffMedical Research Laboratory Unit, Faculty of Medicine, University of Oulu, Oulu, Finland.
Maria C DenisBiomedcode Hellas SA, Vari, Athens, Greece.
Niki KaragianniBiomedcode Hellas SA, Vari, Athens, Greece.
Johanna MyllyharjuECM-Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Markku VarjosaloInstitute of Biotechnology, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Heikki TanilaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Harri M ItkonenDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Mika RämetFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Johanna UusimaaMedical Research Center Oulu and Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Reetta HinttalaMedical Research Center Oulu and Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibrosis, neurodegeneration and cerebral angiomatosis (FINCA) is a childhood-onset neurodevelopmental disorder with multi-organ manifestations, including recurrent infections. It is caused by variants in

Indexed as

FINCA diseaseImmune responseMouse modelNeurodevelopmental disorderNHLRC2NHL repeat containing 2

Identifiers

PMID40510178
PMCPMC12159220

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.