ArticleBrain, behavior, & immunity - health2025
Acute stress-induced alterations in short-chain fatty acids: Implications for the intestinal and blood brain barriers.
Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Plasma short-chain fatty acid concentrations in social anxiety disorder and changes after cognitive behavioral therapy.Translational psychiatry · 2026Article
- Gut microbial diversity and inferred capacity to produce short-chain fatty acids are associated with acute stress reactivity in healthy adults.Neurobiology of stress · 2026Article
- Clozapine disrupts the gut-lung microbiota axis, linking gastrointestinal hypomotility to increased respiratory vulnerability.Translational psychiatry · 2026Article
- Opuntia ficus-indica Flour Modulates Fecal Microbiota, Reduces Cerebral Oxidative Stress and Improves Cognitive Function in Elderly Rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- The interactions of diet, mood, and the gut microbiome during an eight-week submarine deployment.Microbiology spectrum · 2026Article
- Severity of Depressive Symptoms by Perceived Stress and Gut Microbiota Composition: A Sex-Stratified Bayesian Approach in a Non-Clinical Sample.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- Varietal Differences in Kidney Beans Modulate Gut Microbiota and Inflammation During High-Fat Diet-Induced Obesity in Male Mice.Nutrients · 2026Article
- Longitudinal dynamics of the gut microbiome during methamphetamine addiction and abstinence.Frontiers in microbiology · 2026Article
- A taxon-centered review of bacterial shifts in psychiatric disorders.Frontiers in psychiatry · 2026Review
- Microbial tryptophan metabolites modulate blood-brain and gut barriersNeuroscience applied · 2026Article
- Across Barriers: Blood-Brain and Gut Barrier Signaling in Psychiatric Disorders.Journal of neurochemistry · 2025Review
- Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?NPJ biofilms and microbiomes · 2025Review
- An expert narrative review on the mechanisms and therapeutic potential of gut microbiota-derived metabolites in multi-organ crosstalk.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unravelling the features of the whole-body response to acute stress exposures is critical to understand this neglected building block of chronic stress. A single acute stress exposure rapidly modulates gut-brain axis signalling including intestinal permeability, but the mechanisms are unclear. Microbially-produced metabolites such as short-chain fatty acids (SCFA) are key effectors within the gut-brain axis which can affect gut and brain function. The aim of this work is to determine if acute stress regulates SCFA production in the gut and to understand the associated implications for gastrointestinal and brain barrier function. Stress reduced caecal SCFA concentrations, primarily butyrate and acetate. These SCFAs prevented LPS-induced disruption of gut and brain barrier function in a dose-dependent manner in in vitro models. This functional protection was associated with altered tight-junction abundance and morphology. These results provide a better understanding of the role SCFAs have on barriers following acute stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.