Evidence map›Paper›PMID 40510347›Full record

ReviewFrontiers in immunology2025

T lymphocyte heterogeneity in NSCLC: implications for biomarker development and therapeutic innovation.

Yu Liu, Denghui Qin, Jiejun Fu

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Terminally exhausted CD8Frontiers in immunology · 2025
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu Liu *Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Denghui Qin *Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Jiejun FuCenter for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) immunotherapy has been revolutionized by immune checkpoint inhibitors (ICIs), yet response heterogeneity persists due to dynamic tumor-immune interactions. This review summarizes recent studies in understanding tumor-infiltrating lymphocyte (TIL) biology, highlighting CD8

Indexed as

Biomarkers, TumorCarcinoma, Non-Small-Cell LungLung NeoplasmsLymphocytes, Tumor-InfiltratingAnimalsHumansImmune Checkpoint InhibitorsImmunotherapyTumor MicroenvironmentBiomarkers, TumorImmune Checkpoint InhibitorsbiomarkersCD8 + T cellimmunotherapy combination therapymelanomaNRAS mutationsPD-1T lymphocyte

Identifiers

PMID40510347
PMCPMC12159075

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.