ArticleFrontiers in endocrinology2025
Association between physiological serum total bilirubin concentrations and the progression of diabetic nephropathy.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association of Serum Bilirubin Levels With Histopathological Severity of Diabetic Nephropathy in Patients With Type 2 Diabetes: A Cross-Sectional Biopsy Study.Journal of diabetes research · 2026Article
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6 authors.
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Abstract
Purpose: To analyze the relationship between physiological serum total bilirubin (STB) concentrations and the progression of diabetic nephropathy (DN). Methods: The clinical features and pathological data of 159 patients with diabetic nephropathy confirmed by renal biopsy were retrospectively analyzed. They were divided into low bilirubin group (80 cases) and high bilirubin group (79 cases) according to the median of STB level. Clinical and pathological data of the two groups were collected and compared. The patients were followed up from the date of renal biopsy to June 30, 2024. Kaplan-Meier method and log-rank test was used to perform survival analysis. Univariate and multivariate Cox regression risk model were used to analyze the risk factors of diabetic nephropathy. A restricted cubic spline model was used to show the nonlinear association between STB and DN. Results: When compared with physiologically high bilirubin group, patients in low bilirubin group might had higher level of serum creatinine, blood urea nitrogen, 24h urinary protein, urinary albumin to creatinine ratio (UACR), fibrinogen (Fib) and higher rate of Conclusions: Our findings suggest that STB may serve as a potential biomarker for the progression of diabetic nephropathy. Lower STB levels may help identify high-risk patients who could benefit from earlier or more intensive interventions to slow disease progression.
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