ArticleFrontiers in endocrinology2025
Analysis of pathogen distribution and serum procalcitonin level alterations in patients with type 2 diabetes mellitus complicated by urinary tract infections.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Computational-experimental strategy identifies Co-upregulated biomarkers linking coronary heart disease and type 2 diabetes pathogenesis.Frontiers in genetics · 2025Article
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10 authors.
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Abstract
Objective: To investigate the distribution and antibiotic resistance of pathogens in patients with Type 2 Diabetes Mellitus (T2DM) complicated by Urinary Tract Infections (UTIs), and to explore the value of serum Procalcitonin (PCT) level alterations in the diagnosis and assessment of disease severity in these patients. Methods: This retrospective analysis included 100 patients with T2DM complicated by UTIs admitted to the Sixth Affiliated Hospital of Kunming Medical University between January 2021 and August 2024, who constituted the Infection group. A control group, the T2DM group, consisted of 100 patients with T2DM without UTIs. Key demographic data were retrospectively analyzed and evaluated. Bacterial isolation and identification, along with antimicrobial susceptibility testing using an automated analyzer, were performed to determine the distribution and antimicrobial resistance profiles of the isolated pathogens. Serum PCT levels were measured using electrochemiluminescence immunoassay. Receiver Operating Characteristic (ROC) curve analysis was used to evaluate the diagnostic value of PCT for T2DM complicated by UTIs. The optimal cutoff value was calculated using the Youden index derived from the ROC curve. Results: 146 pathogenic strains were isolated from the 200 submitted specimens. Gram-negative bacteria accounted for 66.44% (n=97), Gram-positive bacteria for 14.38% (n=21), and fungi for 19.18% (n=28). Conclusion:
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