ArticlePhotoacoustics2025
Local oxygen concentration reversal from hyperoxia to hypoxia monitored by optical-resolution photoacoustic microscopy in inflammation-resolution process.
Article in Photoacoustics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Noninvasive multimodal photoacoustic-ultrasound imaging for dynamic assessment of placental hypoxia and perfusion in preeclampsia.Photoacoustics · 2026Article
- Sparse scanning encoding and neural network decoding for compressed photoacoustic microscopy.Photoacoustics · 2025Article
- Review of Linear-Array-Transducer-Based Volumetric Ultrasound Imaging Techniques and Their Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current consensus suggests a simultaneous occurrence of hypoxia and inflammation. For the first time, we observed a hyperoxia state during the initiation stage of gouty arthritis (GA) via optical-resolution photoacoustic microscopy. GA as a paradigm of acute sterile inflammation, has been regarded as a single process. However, our experimental results demonstrated that the onset-resolution inflammation process composed of two sub-processes with different features. In the initial sub-process, inflammation and resolution events appear in hyperoxia state (1st-5th days). In the subsequent sub-process, post-resolution events appear in hypoxia state (6th-15th days), which is related with the second wave of immune response. Furthermore, we demonstrated that the inflammatory cytokines together with hyperoxia levels in initial sub-process can be downregulated by photobiomodulation, resulting in the hypoxia levels in subsequent sub-process were inhibited. Our results unveiled the detailed progress of GA and provided potential non-invasive monitoring and treatment strategies.
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Registered trials
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