Evidence mapPaperPMID 40510674Full record

ArticleFrontiers in microbiology2025

Intermittent fasting inhibits the development of colorectal cancer in APC

Jia Chen, Rishun Su, Yulong He, Jiong Chen

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Intermittent fasting enhances cancer therapyWorld journal of clinical oncology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jia Chen *Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China.
Rishun Su *Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China.
Yulong He *Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China.
Jiong Chen *Department of Anesthesiology, The Seventh Affiliated Hospital of Sun Yat-sen University, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: Intermittent fasting is an emerging dietary approach, but its specific role in colorectal cancer (CRC) is not yet clear. In this study, we investigated the relationship between intermittent fasting and colorectal development in mice. Methods: First, APC Results: Intermittent fasting significantly reduced tumor incidence by approximately 50% compared to the control group (1.25 ± 0.38 vs 2.50 ± 0.38 tumors/mouse, Conclusion: Intermittent fasting suppresses CRC development in mice through its effects on gut microbiota and related metabolites.

Indexed as

APCMin/+ micecolorectal cancergut microbiomeintermittent fastingisovaleric acid

Identifiers

PMID40510674
PMCPMC12158919

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.