Evidence map›Paper›PMID 40511045›Full record

ArticleJournal of pharmacy & bioallied sciences2025

Correlation between Histopathological Features and Clinical Outcomes in Patients with Oral Squamous Cell Carcinoma.

Shamita Tiwari, Saurabh Shekhar, Oruganti V Ramanand, Pallavi Mishra, Anish Nelson, Kiran S Shankar, Riddhima Mathur

Abstract read
In one paragraph

Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Early-Onset Oral Squamous Cell Carcinoma: Emerging Biological Insights, Risk Factors and Clinical Implications.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shamita TiwariDepartment of Oral and Maxillofacial Surgery, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
Saurabh ShekharDepartment of Oral Pathology, AIMST University, Bedong, Kedah, Malaysia.
Oruganti V RamanandDepartment of Oral and Maxillofacial Pathology, Nimra Institute of Dental Sciences, Vijayawada, Andhra Pradesh, India.
Pallavi MishraDepartment of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Patia, Bhubaneswar, India.
Anish NelsonDepartment of Oral and Maxillofacial Surgery, AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Nitte (Deemed To Be University), Mangalore, Karnataka, India.
Kiran S ShankarDepartment of Public Health Dentistry, PMS College of Dental Science and Research, Vattapara, Trivandrum, Kerala, India.
Riddhima MathurBDS, Jaipur Dental College, Jaipur, Rajasthan, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy, with histopathological features playing a crucial role in predicting clinical outcomes. Tumor budding, lymphovascular invasion, and depth of invasion are key indicators used to assess prognosis and therapeutic response. The objective of this research is to examine the correlation between these histopathological parameters and patient outcomes. Methods: This retrospective analysis included patients diagnosed with OSCC. The key parameters examined were tumor budding, depth of invasion, and lymphovascular invasion. Clinical outcomes, including recurrence and survival rates, were analyzed. Results: Tumor budding and depth of invasion were significantly associated with increased recurrence rates and poorer survival outcomes. Lymphovascular invasion also showed a strong correlation with advanced disease stages. Conclusion: The histopathological features, particularly tumor budding and depth of invasion, are significant predictors of clinical outcomes in OSCC patients. These features should be emphasized in the prognosis and treatment planning of OSCC.

Indexed as

Clinical outcomesdepth of invasionhistopathologyoral squamous cell carcinomatumor budding

Identifiers

PMID40511045
PMCPMC12156740

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.