Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025
A multidomain trial for cognition in women with cardiovascular disease.
Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04556305 (Lifestyle Physical Activity and Cognitive Training Interventions), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lifestyle Physical Activity and Cognitive Training Interventions: Preventing Memory Loss in Older Women With Cardiovascular Disease
Who cites it
1 citing paper in PubMed.
- Cognitive Training Intervention Adherence in Older Women with Cardiovascular Disease: A Secondary Analysis of the MindMoves Trial.The Journal of cardiovascular nursingTrial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionWe evaluated the independent and combined efficacies of MindMoves (24-week physical activity and cognitive training) on cognition and serum neurotrophic biomarkers in older women with cardiovascular disease (CVD).
methodsThis 2 × 2 factorial design randomized controlled trial (NCT04556305) tested efficacies of Mind (cognitive training) and Move (lifestyle physical activity) on change in cognition (global composite derived from three domains) and four serum biomarkers at baseline, 24, 48, and 72 weeks post-baseline in older women with CVD without cognitive impairment.
resultsOf 253 participants randomized (mean age = 72.8; 57% non-Hispanic White), 87% completed the trial, though health-behavior adherence was low (Mind 45%, Move 33%). Interventions were not significant for global cognition. There were Mind x Move interaction effects for semantic memory and one biomarker, but these were counter to the hypothesized synergistic effects. DISCUSSION: Mind and Move, alone or in combination, were not associated with improved cognition in this sample. Future research should emphasize adherence. CLINICAL TRIAL REGISTRATION NUMBER: NCT04556305. HIGHLIGHTS: This trial evaluated the efficacy of a lifestyle intervention in women with cardiovascular disease. The trial did not show a significant difference in global cognition. There were significant effects of physical activity on secondary outcomes. Future research should focus on adequate intervention adherence and intensity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.