Evidence map›Paper›PMID 40512033›Full record

ArticleInfection and immunity2025

Proteomic profiling reveals immunomodulatory role of IL-33 in ocular bacterial and fungal infections.

Zeeshan Ahmad, Sukhvinder Singh, Dhanwini Rudraprasad, Joveeta Joseph, Nikhlesh K Singh, Ashok Kumar

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zeeshan AhmadDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA.ORCID 0000-0001-8667-1312
Sukhvinder SinghDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA.
Dhanwini RudraprasadJhaveri Microbiology Centre, Brien Holden Eye Research Centre, L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
Joveeta JosephJhaveri Microbiology Centre, Brien Holden Eye Research Centre, L.V. Prasad Eye Institute, Hyderabad, Telangana, India.ORCID 0000-0002-8421-1977
Nikhlesh K SinghDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA.
Ashok KumarDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA.ORCID 0000-0001-6332-6591

Funding

VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
Targeting NAD metabolism to ameliorate bacterial endophthalmitisR01EY026964 · NEI · WAYNE STATE UNIVERSITY · PI Ashok Kumar · 2017 to 2026
$3.7M
Mechanisms of Inflammation Resolution in Bacterial EndophthalmitisR01EY027381 · NEI · WAYNE STATE UNIVERSITY · PI Ashok Kumar · 2017 to 2026
$3.3M
Vitreous metabolic perturbations during bacterial and fungal endophthalmitisR01EY035499 · NEI · WAYNE STATE UNIVERSITY · PI Ashok Kumar · 2024 to 2026
$1.3M
NEI NIH HHS P30 EY004068NEI NIH HHS P30EY004068NEI NIH HHS R01 EY026964NEI NIH HHS R01 EY027381NEI NIH HHS R01 EY035499NIH HHS R01EY026964NIH HHS R01EY027381NIH HHS R01EY035499
6 · The paper itself

Abstract

Bacterial and fungal pathogens are major causes of infectious endophthalmitis following eye surgery or trauma, often leading to vision impairment or blindness. The distinct clinical outcomes observed in bacterial and fungal endophthalmitis suggest differences in host immune responses. To investigate these differences, we utilized cytokine arrays and murine models of bacterial (

Indexed as

AspergillosisEndophthalmitisEye Infections, BacterialEye Infections, FungalInterleukin-33Staphylococcal InfectionsAnimalsAspergillus fumigatusCytokinesDisease Models, AnimalHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutProteomicsCytokinesIL33 protein, humanInterleukin-33cell deathendophthalmitisIL-33inflammationproteomic profilerretina

Identifiers

PMID40512033
PMCPMC12234442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.