Evidence map›Paper›PMID 40512240›Full record

ArticleBasic research in cardiology2025

Molecular screening in a translational large animal trial identifies a differential inflammatory response for MINOCA.

Jasper Iske, Joshua M Mesfin, Petra Wolint, Miriam Weisskopf, Christien Beez, Henriette Thau, Christian T Stoeck, January M Weiner, Melanie M Hierweger, Eva van Gelder and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jasper IskeDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Joshua M MesfinDepartment of Health Sciences and Technology, ETH Zürich, Leopold-Ruzicka-Weg 4, HCP H 12.1, Zurich, Switzerland.
Petra WolintDepartment of Health Sciences and Technology, ETH Zürich, Leopold-Ruzicka-Weg 4, HCP H 12.1, Zurich, Switzerland.
Miriam WeisskopfCenter for Preclinical Development, University Hospital of Zürich, University of Zürich, Zurich, Switzerland.
Christien BeezDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Henriette ThauDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Christian T StoeckCenter for Preclinical Development, University Hospital of Zürich, University of Zürich, Zurich, Switzerland.
January M WeinerBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Melanie M HierwegerCenter for Preclinical Development, University Hospital of Zürich, University of Zürich, Zurich, Switzerland.
Eva van GelderDepartment of Health Sciences and Technology, ETH Zürich, Leopold-Ruzicka-Weg 4, HCP H 12.1, Zurich, Switzerland.
Thorald StolteDepartment of Health Sciences and Technology, ETH Zürich, Leopold-Ruzicka-Weg 4, HCP H 12.1, Zurich, Switzerland.
Nuri ÜnesenDepartment of Health Sciences and Technology, ETH Zürich, Leopold-Ruzicka-Weg 4, HCP H 12.1, Zurich, Switzerland.
Ross StraughanDepartment of Health Sciences and Technology, ETH Zürich, Leopold-Ruzicka-Weg 4, HCP H 12.1, Zurich, Switzerland.
Lucas S J EckholtDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Nina TrimmelCenter for Preclinical Development, University Hospital of Zürich, University of Zürich, Zurich, Switzerland.
Dieter BeuleBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Heike MeyborgDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Timo Z Nazari-ShaftiDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Volkmar FalkDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Maximilian Y EmmertDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany.
Nikola CesarovicDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Der Charité (DHZC), Berlin, Germany. nikola.cesarovic@hest.ethz.ch.ORCID 0000-0001-6744-2928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction without obstructive coronary arteries (MINOCA) comprises up to 15% of all myocardial infarctions (MI) and could be caused by cardiac microembolization (CME) originating from plaque rupture and/or erosion. Early diagnosis remains a challenge due to limited early biomarkers, leading to high morbidity. Here, we have systematically characterized acute (up to 5 h) CME-induced MINOCA in comparison to MI using clinical markers, histology, multi-ELISAs, miRNA profiling, and proteomics in a translational porcine animal model. CME-induced MINOCA model was created by injecting autologous microthrombi, generated by carotid crush maneuver, into the coronary arteries, whereas MI was induced by LAD balloon occlusion/reperfusion. MINOCA animals exhibited low troponin (547.0 ± 489.2 ng/L) and creatine kinase (1827.8 ± 677.3 U/L) levels, as well as infarct size (2.3 ± 0.8%), necrosis (7.6 ± 3.2%), and interstitial hemorrhage (0.6 ± 0.4%). Immune cell infiltration surrounding MINOCA microthrombi sites was significantly higher (1532 ± 722 cells/mm

Indexed as

EmbolismInflammationInflammation MediatorsMyocardial InfarctionAnimalsBiomarkersDisease Models, AnimalMaleMicroRNAsProteomicsSwineTranslational Research, BiomedicalBiomarkersInflammation MediatorsMicroRNAsInflammationLeukotrieneMIMicrocirculationMINOCAThrombosis

Identifiers

PMID40512240
PMCPMC12325550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.