ArticleScience advances2025
Abscisic acid enhances DNA damage response through the nuclear shuttling of clathrin light chain 2 in plant cells.
Jieming Jiang, Qiuhua Zhu, Yang Li, Jiayuan Wu, Chenghuan Zou, Hongbo Li, Xiaohui Lei, Fangyuan Zhang, Yujie Lin, Rui Cao and 6 more
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In one paragraphArticle in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
16 authors.
Jieming JiangGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.ORCID 0000-0002-7163-7477 Yang LiGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Jiayuan WuGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.ORCID 0009-0003-3202-2036 Chenghuan ZouGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Hongbo LiGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.ORCID 0000-0002-5654-1928 Xiaohui LeiGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Fangyuan ZhangGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Yujie LinGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Rui CaoGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Ying CaoGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Jiawang MoGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.
Jianbin LaiGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.ORCID 0000-0002-9269-9052 Chengwei YangGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China.ORCID 0000-0002-2648-3181 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
DNA damage arises from various environmental stresses, and ABA is well known for its roles in plant stress resistance. However, its function in plant DNA damage tolerance remains unclear. In this study, we showed that ABA supplementation significantly enhances plant tolerance to DNA-damaging treatments. SnRK2.2 and SnRK2.3 kinases in the ABA signaling pathway are pivotal in this process. These kinases interact with clathrin light chain 2 (CLC2), facilitating its phosphorylation and nuclear translocation in response to Zeocin and ABA treatment. In the nucleus, CLC2 interacts with ADA2b, an adaptor protein crucial for recruiting SMC5/6 complex to the double-strand break (DSB) sites. The enhanced nuclear localization of CLC2 is essential for the accurate localization of ADA2b at DSB sites. Collectively, our study uncovers that ABA enhances plant DNA damage tolerance with a distinct function of CLC2 in genomic stability maintaining, thereby improving our understanding of DNA damage tolerance mechanisms in plants.
Indexed as
Abscisic AcidArabidopsisClathrin Light ChainsDNA DamagePlant CellsActive Transport, Cell NucleusArabidopsis ProteinsBleomycinCLC-2 Chloride ChannelsPhosphorylationPlants, Genetically ModifiedProtein Serine-Threonine KinasesTranscription FactorsAbscisic AcidADA2b protein, ArabidopsisArabidopsis ProteinsBleomycinClathrin Light ChainsCLC-2 Chloride ChannelsProtein Serine-Threonine KinasesSnRK2 protein, ArabidopsisTranscription FactorsZeocin
Identifiers
PMID40512838
PMCPMC12164954
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