Evidence map›Paper›PMID 40513614›Full record

ReviewBiofabrication2025

3D bioprinting in tissue engineering: current state-of-the-art and challenges towards system standardization and clinical translation.

Tarun Agarwal, Valentina Onesto, Dishary Banerjee, Shengbo Guo, Alessandro Polini, Caleb Vogt, Abhishek Viswanath, Timothy Esworthy, Haitao Cui, Aaron O'Donnell and 7 more

Abstract readReview
In one paragraph

Review in Biofabrication, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  4. Article
  5. Computational approaches in bioprinting processes.Nature reviews bioengineering · 2026
    Article
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  18. 3D Bioprinting Strategies in Autoimmune Disease Models.International journal of molecular sciences · 2025
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tarun AgarwalDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, United States of America.ORCID 0000-0002-3300-7781
Valentina OnestoCenter for Advanced Biomaterials for Health Care, Istituto Italiano di Tecnologia (IIT@CRIB), Naples 80125, Italy.ORCID 0000-0002-2308-4126
Dishary BanerjeeEngineering Science and Mechanics Department, The Pennsylvania State University, University Park, PA, United States of America.
Shengbo GuoDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, United States of America.
Alessandro PoliniInstitute of Nanotechnology, National Research Council (CNR-NANOTEC), Campus Ecotekne, via Monteroni, Lecce 73100, Italy.ORCID 0000-0002-3188-983X
Caleb VogtMedical Scientist Training Program, University of Minnesota-Twin Cities, Minneapolis, MN 55455, United States of America.ORCID 0000-0002-2164-2024
Abhishek ViswanathInstitute of Physical Chemistry, Polish Academy of Sciences, Warsaw 01-224, Poland.
Timothy EsworthyDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, United States of America.
Haitao CuiKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, People's Republic of China.
Aaron O'DonnellDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States of America.
Kiran Yellappa VajanthriDepartment of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad, Telangana 500075, India.
Lorenzo MoroniMERLN Institute for Technology-Inspired, Regenerative Medicine, Department of Complex Tissue Regeneration, Maastricht University, Universiteitssingel 40, 6229ER Maastricht, The Netherlands.ORCID 0000-0003-1298-6025
Ibrahim T OzbolatEngineering Science and Mechanics Department, The Pennsylvania State University, University Park, PA, United States of America.ORCID 0000-0001-8328-4528
Angela Panoskaltsis-MortariDepartment of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota-Twin Cities, Minneapolis, MN 55455, United States of America.ORCID 0000-0003-1802-1785
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, United States of America.ORCID 0000-0003-3009-045X
Marco CostantiniInstitute of Physical Chemistry, Polish Academy of Sciences, Warsaw 01-224, Poland.ORCID 0000-0003-2756-5872
Tapas Kumar MaitiDepartment of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.ORCID 0000-0002-3984-5911

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
A dual 3D bioprinting platform for engineering a thick anisotropic myocardial tissue with geometric vasculatureR01HL171317 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI Muhammad M Mohiuddin, Lijie Grace Zhang · 2024 to 2026
$1.5M
NHLBI NIH HHS R01 HL171317NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

Over the past decade, three-dimensional (3D) bioprinting has made significant progress, transforming into a key innovation in tissue engineering. Despite the early strides, critical challenges remain in 3D bioprinting that must be addressed to accelerate clinical translation. In particular, there is still a long way to go before functionally-mature, clinically-relevant tissue equivalents are developed. Current limitations range from the sub-optimal bioink properties and degree of biomimicry of bioprintable architectures, to the lack of stem/progenitor cells for massive cell expansion, and fundamental knowledge regarding

Indexed as

BioprintingPrinting, Three-DimensionalTissue EngineeringAnimalsHumansTissue Scaffolds3D bioprinting4D bioprintingbioinksbiomaterialstissue engineering

Identifiers

PMID40513614
PMCPMC12906674

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.