Evidence map›Paper›PMID 40514065›Full record

SynthesisJournal for immunotherapy of cancer2025

Predictive value of preclinical models for CAR-T cell therapy clinical trials: a systematic review and meta-analysis.

David Andreu-Sanz, Lisa Gregor, Emanuele Carlini, Daniele Scarcella, Carsten Marr, Sebastian Kobold

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Organoid technology in cancer research.Molecular biomedicine · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. In Vivo T-Cell Engineering: Revolution in Delivery Strategies and Clinical Translation.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David Andreu-Sanz *Division of Clinical Pharmacology, LMU Klinikum, Member of the German Center for Lung Research (DZL), Munich, Germany.
Lisa Gregor *Division of Clinical Pharmacology, LMU Klinikum, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0002-3300-7167
Emanuele Carlini *Division of Clinical Pharmacology, LMU Klinikum, Member of the German Center for Lung Research (DZL), Munich, Germany.
Daniele Scarcella *Institute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Carsten MarrInstitute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Sebastian KoboldDivision of Clinical Pharmacology, LMU Klinikum, Member of the German Center for Lung Research (DZL), Munich, Germany sebastian.kobold@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-5612-4673

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunotherapy, AdoptiveNeoplasmsReceptors, Chimeric AntigenT-LymphocytesAnimalsClinical Trials as TopicDisease Models, AnimalHumansMiceReceptors, Chimeric AntigenChimeric antigen receptor - CARHematologic MalignanciesMETA-ANALYSISSolid tumorT cell

Identifiers

PMID40514065
PMCPMC12164627

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.