Evidence map›Paper›PMID 40514200›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Endothelial TERT drives microvascular phenotype associated with coronary artery disease.

Erin C Birch, Yoshinori Nishijima, Shelby N Hader, Andreas M Beyer

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erin C BirchDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0001-9860-1370
Yoshinori NishijimaDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-5547-4508
Shelby N HaderDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-6564-091X
Andreas M BeyerDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0001-9129-7492

Funding

Pivotal Role of Mitochondrial Telomerase in Regulation of Vascular Tone and Redox HomeostasisR01HL133029 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2017 to 2021
$2.2M
Critical role of Mitochondrial Fission/Fusion in Regulation of Microvascular Endothelial FunctionR01HL157025 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2021 to 2024
$2.1M
Mechanism of Chemotherapy Induced Microvascular Dysfunction in Cancer SurvivorsR01HL173549 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Andreas M Beyer · 2024 to 2026
$2.1M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL157025HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL173549NHLBI NIH HHS R01 HL133029NHLBI NIH HHS R01 HL157025NHLBI NIH HHS R01 HL173549
6 · The paper itself

Abstract

Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed that under pathological states, such as coronary artery disease (CAD), the dilation mechanism switches from nitric oxide (NO)-mediated [determined by NO synthase (NOS) inhibitor] to mitochondria-derived H

Indexed as

Coronary Artery DiseaseEndothelial CellsEndothelium, VascularMesenteric ArteriesMicrocirculationMicrovesselsTelomeraseVasodilationAcetylcholineAnimalsDisease Models, AnimalHydrogen PeroxideMaleMiceMice, Inbred C57BLMice, KnockoutAcetylcholineHydrogen PeroxideNitric OxideTelomeraseTert protein, mouseVasodilator Agentsendothelial cellsmicrocirculationtelomerasetelomerase reverse transcriptase

Identifiers

PMID40514200
PMCPMC12233018

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.