Evidence map›Paper›PMID 40514563›Full record

ArticleNature microbiology2025

Murine maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehaviour.

Elena J Coley-O'Rourke, Gregory R Lum, Geoffrey N Pronovost, Lewis W Yu, Ezgi Özcan, Kristie B Yu, Janet McDermott, Anna Chakhoyan, Eliza Goldman, Helen E Vuong and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Elena J Coley-O'RourkeDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA. ecoley7@g.ucla.edu.ORCID http://orcid.org/0009-0003-2802-1372
Gregory R LumDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Geoffrey N PronovostDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Lewis W YuDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Ezgi ÖzcanDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5365-1550
Kristie B YuDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Janet McDermottDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Anna ChakhoyanDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Eliza GoldmanDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Helen E VuongDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Jorge ParamoUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Sydney McCuneDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (LRF MOMI CORE) and Human Milk Institute (HMI), University of California San Diego, La Jolla, CA, USA.
Kristija SejaneDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (LRF MOMI CORE) and Human Milk Institute (HMI), University of California San Diego, La Jolla, CA, USA.
Simone RenwickDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (LRF MOMI CORE) and Human Milk Institute (HMI), University of California San Diego, La Jolla, CA, USA.
Lars BodeDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (LRF MOMI CORE) and Human Milk Institute (HMI), University of California San Diego, La Jolla, CA, USA.
Alison ChuDivision of Neonatology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Kara L CalkinsDivision of Neonatology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Elaine Y HsiaoDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA. ehsiao@g.ucla.edu.ORCID http://orcid.org/0000-0002-1633-588X

Funding

Uncovering Microbial Modifiers of Antidepressant Responses during PregnancyR01HD111079 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elaine Hsiao · 2023 to 2026
$2.0M
National Science Foundation (NSF) Graduate Research FellowshipNICHD NIH HHS R01 HD111079U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1R01HD111079
6 · The paper itself

Abstract

Protein undernutrition results in impaired growth and neurobehavioural development in children. However, the impact of timing, environmental factors and maternal versus neonatal influences are unclear. Here, using a mouse model of fetal growth restriction where maternal protein intake is limited during pregnancy, we show that adult offspring exhibit cognitive and anxiety-like behavioural abnormalities. Cross-fostering newborn mice to dams previously exposed to either low protein or standard diet reveals that behavioural impairments in adult offspring require diet-induced conditioning of both fetal development and maternal peripartum physiology. Maternal gut microbiome diversity is reduced, maternal immune, milk, and serum metabolomic profiles are altered, and widespread changes in fetal brain transcriptomic and metabolomic profiles are observed, including subsets of microbiome-dependent metabolites. Finally, we show that dam treatment with a cocktail of ten diet- and microbiome-dependent metabolites results in differential effects on fetal development and postnatal behaviour. Our study highlights the impact of prenatal maternal protein undernutrition on offspring neurobehavioural trajectories and the role of the maternal microbiome.

Indexed as

Behavior, AnimalGastrointestinal MicrobiomeMalnutritionPrenatal Exposure Delayed EffectsAnimalsAnimals, NewbornBrainDisease Models, AnimalFemaleFetal DevelopmentFetal Growth RetardationMaleMaternal Nutritional Physiological PhenomenaMiceMice, Inbred C57BLPregnancy

Identifiers

PMID40514563
PMCPMC13178685

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.