Evidence map›Paper›PMID 40514574›Full record

ArticleBiomechanics and modeling in mechanobiology2025

The impact of coronary outflow and non-Newtonian fluid property on aortic valve haemodynamics.

Zhongjie Yin, Chlöe Armour, Harkamaljot Kandail, Declan P O'Regan, Toufan Bahrami, Saeed Mirsadraee, Selene Pirola, Xiao Yun Xu

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In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhongjie YinDepartment of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK.
Chlöe ArmourDepartment of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK.
Harkamaljot KandailMedtronic Neurovascular, Irvine, CA, USA.
Declan P O'ReganLaboratory of Medical Sciences, Imperial College London, London, UK.
Toufan BahramiNational Heart and Lung Institute, Imperial College London, London, UK.
Saeed MirsadraeeNational Heart and Lung Institute, Imperial College London, London, UK.
Selene PirolaDepartment of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK.
Xiao Yun XuDepartment of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK. yun.xu@imperial.ac.uk.

Funding

British Heart Foundation RE/18/4/34215Department of Chemical Engineering, Imperial College London PhD scholarshipMedical Research Council MC_UP_1605/13National Institute for Health and Care Research RG/19/6/34387
6 · The paper itself

Abstract

The normal healthy aortic valve (AoV) has three leaflets, two of which have outflows to the coronary arteries. Blood flow through the coronary ostia will have an impact on AoV dynamics and the surrounding haemodynamics, leading to differential shear stress distributions at the aortic side of the three leaflets. In addition, aortic root haemodynamics may also be influenced by the non-Newtonian behaviour of blood which is known as a shear-thinning fluid due to the aggregation of red blood cells at low shear rate. However, the combined effect of coronary and non-Newtonian flow on AoV haemodynamics has not been studied in an anatomically realistic setting. In this study, strongly coupled fluid-structure interaction (FSI) analyses were performed on a natural, healthy AoV, with and without accounting for coronary outflows and non-Newtonian properties of blood. Our results showed that the influence of coronary outflow is more pronounced than employing a non-Newtonian model, and their combined effect is non-negligible, particularly on wall shear stress. Incorporating coronary outflow and non-Newtonian properties increased time-averaged wall shear stress (TAWSS) in the aortic sinus by up to 108.45%; it also increased TAWSS on the aortic side of valve leaflets by 41.04%, 44.76%, and 54.91% on the left, right and non-coronary leaflet, respectively. These results highlight the importance of incorporating coronary outflow and non-Newtonian properties when accurate predictions of wall shear stress and its related parameters are critical.

Indexed as

Aortic ValveCoronary CirculationHemodynamicsStress, MechanicalHumansAortic valveCoronary outflowFluid–structure interactionNon-Newtonian blood propertyWall shear stress

Identifiers

PMID40514574
PMCPMC12245955

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.