Evidence map›Paper›PMID 40514659›Full record

ArticleJournal of nanobiotechnology2025

Nano-orchestrated magnetotactic-like navigation for electromagnetic theranostics and immune enhancement via photoautotrophic oxygenation, mild hyperthermia, and ferroptosis.

Chi-Hung Hsiao, Yung-Wei Lin, Chia-Hung Liu, Yan-Ting Chen, Hieu Trung Nguyen, Andrew E-Y Chuang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Phase-Dependent MoSInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chi-Hung Hsiao *Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, New Taipei City, 235603, Taiwan.
Yung-Wei Lin *Department of Urology, Wan Fang Hospital, Taipei Medical University, 111 Hsing Long Road, Section 3, Taipei, 11696, Taiwan.
Chia-Hung Liu *TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, 11031, Taiwan.
Yan-Ting Chen *Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, New Taipei City, 235603, Taiwan.
Hieu Trung NguyenDepartment of Orthopedics and Trauma, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 700000, Viet Nam.
Andrew E-Y ChuangGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, New Taipei City, 235603, Taiwan. eychuang@tmu.edu.tw.

Funding

NSTC 112-2221-E-038-002-MY3
6 · The paper itself

Abstract

Overcoming the hypoxic tumor microenvironment (TME) and immune suppression remains a significant challenge in solid bladder tumor therapies. This study introduces a translational system of nano-orchestrated magnetotactic-like system, integrating photosynthetic oxygenation, remote hyperthermia, and ferroptosis to achieve comprehensive tumor eradication and immune activation. The developed system, composed of electromagnetic-responsive iron oxide nanoparticles (IO NPs) encapsulated within a glycol chitosan (GCS) matrix and coated onto Chlorella (CHL; CHL-GCS-IO NPs), exhibited versatility for precise magnetic targeting, photothermal-hypertehrmia and photosynthesis-driven oxygen generation under light irradiation. The CHL enhanced oxygen production by continuously alleviating hypoxia, boosting both electromagnetic therapeutic efficacies and ferroptosis-induced tumor cell death. Moreover, the multimodal CHL-GCS-IO NPs reprogrammed the TME, facilitating immune activation by promoting macrophage polarization towards the proinflammatory M1 phenotype, engaging cytotoxic T cells and natural killer cells, programmed death ligand 1 (PD-L1) downregulation, and driving dendritic cell reprogramming towards improved antigen presentation. In vivo, this approachsuggested significant tumor growth inhibition and prevented recurrence in bladder cancer models, highlighting its potential for robust and durable anticancer immunity. This magnetotactic-like CHL platform presents a highly promising theranostic strategy, merging multimodal therapies with immune modulation to tackle both direct and systemic challenges of solid bladder tumors.

Indexed as

FerroptosisHyperthermia, InducedMagnetic Iron Oxide NanoparticlesTheranostic NanomedicineUrinary Bladder NeoplasmsAnimalsCell Line, TumorChitosanChlorellaFemaleHumansMiceOxygenTumor MicroenvironmentChitosanOxygenElectromagnetic theranosticImmune augmentationMagnetotactic-like systemPhotoautotrophic oxygenation

Identifiers

PMID40514659
PMCPMC12164064

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.