ArticleNutrition journal2025
Mendelian randomization study of micronutrients and development of CKD in a Korean population.
Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlthough dietary intake is a key modifiable risk factor in the development of chronic kidney disease (CKD), the optimal consumption levels to prevent CKD and the intake levels that pose the least risk remain unclear. Building on the findings from our previous cohort study, this research aims to use genetic variants as instrumental variables to clarify the complex relationship between micronutrient status and the pathogenesis of CKD.
methodsOf 5,078 participants with a baseline estimate glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m
resultsIn Mendelian randomization study, using the inverse variance-weighted (IVW) radial method, dietary vitamin B6 (β = -4.016, p-value = 8.72E-05) and C (β = 2.573, p = 1.41E-05) intake levels demonstrated significant associations with the development of CKD. However, there was no significant association observed for dietary phosphorus and vitamin B2 intake levels with the development of CKD (p > 0.05).
conclusionsThis study found a weak causal link to genetically predicted levels of vitamins B6 and C on CKD development. Given potential residual pleiotropy and biological limitations, findings should be cautiously interpreted yet highlight the possible role of balanced micronutrient intake in kidney health.
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