Evidence map›Paper›PMID 40515377›Full record

ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2025

Evaluation of the Dermatoprotective Properties of Clinopodium nepeta and Thymus vulgaris Essential Oils: Phytochemical Analysis, Anti-Elastase, Anti-Tyrosinase, Photoprotective Activities, and Antimicrobial Potential Against Dermatopathogenic Strains.

Mohamed Taibi, Amine Elbouzidi, Nour Eddine Bentouhami, Mounir Haddou, Abdellah Baraich, Yousra Hammouti, Yousra Belbachir, Reda Bellaouchi, Ramzi A Mothana, Mohammed F Hawwal and 5 more

Abstract read
In one paragraph

Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mohamed TaibiLaboratory of Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Amine ElbouzidiLaboratory of Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda, Morocco.ORCID https://orcid.org/0000-0003-0314-8484
Nour Eddine BentouhamiLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Mounir HaddouLaboratory of Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Abdellah BaraichLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Yousra HammoutiLaboratory of Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Yousra BelbachirDepartment of Chemistry, Physical Chemistry of Natural Resources and Process Team, Laboratory of AppliedChemistry and Environment (LCAE), Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Reda BellaouchiLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Ramzi A MothanaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohammed F HawwalDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abdeslam AsehraouLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Salwa KarbouneDepartment of Food Science and Agricultural Chemistry, Macdonald Campus, Quebec, Canada.
Mohamed AddiLaboratory of Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda, Morocco.ORCID https://orcid.org/0000-0002-3973-6694
Bouchra El GuerroujLaboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Khalid ChaabaneLaboratory of Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda, Morocco.

Funding

King Saud University
6 · The paper itself

Abstract

backgroundThe growing demand on natural ingredients in cosmetics has immensely contributed to a renewed interest in cosmetic industry in plant derivatives, especially essential oils. The aim of this study is to examine the dermatoprotective and antifungal properties of Clinopodium nepeta (CNEO) and Thymus vulgaris (TVEO) essential oils. MATERIALS AND

methodsGas chromatography-mass spectrometry (GC-MS) analysis was performed to identify the chemical composition of the essential oils. Anti-elastase and anti-tyrosinase activities were evaluated using standard enzymatic inhibition assays, and IC

resultsGC-MS analysis revealed the presence of 13 compounds in CNEO, mainly oxygenated monoterpenes (91.9%) with pulegone (42.3%) as the main component, and 25 compounds in TVEO, with α-terpineol (19.8%) and carvacrol (13.5%) as the dominant compounds. CNEO showed superior anti-elastase activity (IC

conclusionThis study provides the first comprehensive assessment of the dermatoprotective, antifungal, and antibacterial activities of CNEO and confirms the potential of TVEO in cosmetic, antifungal, and antibacterial applications. The results suggest that these essential oils could serve as promising natural ingredients in dermatoprotective, antifungal, and antibacterial formulations.

Indexed as

Anti-Infective AgentsLamiaceaeMonophenol MonooxygenaseOils, VolatilePlant OilsSunscreening AgentsThymus PlantAntifungal AgentsGas Chromatography-Mass SpectrometryHumansMicrobial Sensitivity TestsPhytochemicalsPlant ExtractsAntifungal AgentsAnti-Infective AgentsMonophenol MonooxygenaseOils, VolatilePhytochemicalsPlant ExtractsPlant OilsSunscreening Agentsantibacterialanti‐elastaseantifungalanti‐tyrosinaseClinopodium nepetaphotoprotectionThymus vulgaris

Identifiers

PMID40515377
PMCPMC12165951

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.