SynthesisPhysiological reports2025
Systematic review and meta-analysis of the effect of exercise training on asprosin in randomized controlled trials.
Synthesis in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Trial
- Ashwagandha Does Not Enhance the Effect of High-Intensity Interval Training on Selected Energy Metabolism Parameters in Young Healthy Men.Nutrients · 2025Trial
- Effects of MICT and HIIT on mitochondrial dynamics-related proteins in visceral adipose tissue of type 2 diabetic rats.Biological research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asprosin, a protein that enhances insulin resistance by stimulating hepatic glucose secretion, is linked to obesity, metabolic disorders, and cardiovascular diseases. This systematic review and meta-analysis investigate the influence of exercise training (ET) on circulating concentrations of asprosin. A systematic search of PubMed, Web of Science, and Google Scholar databases was conducted for all randomized controlled clinical trials from January 2016 to November 2024. A total of 431 relevant articles were retrieved and screened according to the study population, intervention method, and study type, resulting in the selection of 14 articles for the meta-analysis. All statistical results were analyzed using Comprehensive Meta-Analysis Software version 2 (CMA2). The overall effect size, using Hedges' g, based on the random effects model for asprosin with ET, was -1.70 (95% CI -2.17 to -1.23, p = 0.0001). A decrease in asprosin concentration was observed with all types of ET including aerobic training (AT, H = -1.71, p = 0.0001), high-intensity interval training (HIIT, H = -1.81, p = 0.001), and resistance training (RT, H = -1.62, p = 0.0001). Furthermore, subgroup analysis showed differences in asprosin based on body mass index (Q-value = 11.09, df = 2, p = 0.004) and health status of the subjects (Q-value = 12.64, df = 2, p = 0.002); however, there were no differences based on sex (p = 0.67), types (p = 0.96), and duration (p = 0.34) of training. Our findings suggest that ET is associated with a decrease in circulating asprosin that could have a beneficial effect in preventing metabolic disease that is enhanced with obesity. Systematic review registration PROSPERO: CRD42023468813.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.