ArticleEuropean heart journal. Quality of care & clinical outcomes2025
Trends and projections of heart failure among adolescents and young adults: an in-depth analysis for the Global Burden of Disease Study 2021.
Article in European heart journal. Quality of care & clinical outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of new tetralogy drugs on ventricular remodeling in heart failure patients: a systematic review and network meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Review
- Impact of diets high in trans-fatty acids on cardiovascular diseases in adults aged 55 and older: insights from the Global Burden of Disease 2021 data.Frontiers in nutrition · 2026Article
- Trends in United States mortality among patients with atrial fibrillation/flutter related heart failure (1999-2024): disparities by gender, race/ethnicity and region.BMC cardiovascular disorders · 2025Article
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Authors and funding
30 authors.
Funding
Abstract
aimsThe prevalence of heart failure (HF) continues to rise with a growing impact on younger populations, while epidemiological comprehensive data on HF in adolescents and young adults remain scarce. This study aimed to report population shifts and HF burden among individuals aged 15-49 years from 1990 to 2021, with projections through 2035. METHODS AND
resultsData were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 for individuals aged 15-49 years. We investigated the population shift and analysed the temporal trend in HF prevalence and years lived with disability (YLDs) from 1990 to 2021 using the estimated annual percentage change (EAPC) and age-period-cohort (APC) model. We also assessed the underlying causes of HF and examined the associations between Sociodemographic Index (SDI) and the prevalence and YLDs of HF using Pearson correlation. Finally, the Bayesian age-period-cohort (BAPC) model was employed to project HF burdens through 2035. Between 1990 and 2021, global HF prevalence among individuals aged 15-49 years increased by 76.76% (95% uncertainty interval: 71.02, 83.33), with the most substantial growth observed in the African region (2.67-fold), Eastern Mediterranean region (2.63-fold), and South-East Asia region (2.00-fold). By 2021, global HF prevalence reached 7048.1 thousand (5968.4, 8317.3). Males consistently demonstrated higher HF burdens than females across all World Health Organization (WHO) regions. Ischaemic heart disease emerged as the primary contributor to HF prevalence and YLDs worldwide. SDI showed positive correlations with both HF prevalence rate in 2021 and their percentage changes from 1990 to 2021 in specific WHO regions. Projections suggest global HF prevalence will rise to 8115.4 thousand cases (5754.7, 10476.1) by 2035.
conclusionFrom 1990 to 2021, the youths and young adults of 15-49 years worldwide experienced escalating HF burdens marked by significant spatial heterogeneities and sexual differences. The imperative of taking action to reduce the HF burden among the younger population should be tailored to countries characterized by different socio-economic development levels.
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