Evidence map›Paper›PMID 40515944›Full record

ReviewCurrent neurology and neuroscience reports2025

Virus Against Cancer: Paradigm-Shifting Biological Concepts.

Dong Ho Shin, Marta M Alonso, Candelaria Gomez-Manzano, Juan Fueyo

Abstract readReview
In one paragraph

Review in Current neurology and neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dong Ho ShinDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Marta M AlonsoNavarra Institute for Health Research (IdISNA), Pamplona, Spain.
Candelaria Gomez-Manzano *Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. cmanzano@mdanderson.org.
Juan Fueyo *Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. jfueyo@mdanderson.org.

Funding

Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo, FREDERICK F LANG · 2008 to 2026
$41.2M
NCI Diversity Supplement: Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvantsR01CA256006 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FUEYO, JUAN, GOMEZ-MANZANO, CANDELARIA · 2021 to 2025
$2.0M
Examining the Role of Nono Pathway on the Innate Immunity Against Oncolytic AdenovirusesR21CA283514 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo, Candelaria Gomez-Manzano · 2025 to 2026
$420k
Alliance for Cancer Gene Therapy N/AJohn and Rebekah Harper Fellowship N/ANCI NIH HHS P50 CA127001NCI NIH HHS R01 CA256006NCI NIH HHS R01CA256006NCI NIH HHS R21 CA283514The Chance for Life Foundation N/AThe Cure Starts Now Foundation N/A
6 · The paper itself

Abstract

purpose of reviewVirotherapy has emerged as a promising approach to cancer treatment. Over the past two decades, early-phase clinical trials have demonstrated the safety and promising efficacy of virotherapy in subsets of cancer patients. However, a significant knowledge gap needs to be filled to propel the field further and achieve substantial anti-cancer benefits for more than the current 10-20% of treated patients. This article reviews the most relevant current challenges in cancer virotherapy. RECENT

findingsRecent clinical observations suggest that patients who respond to virotherapy experience a shift in their immune response from an initial or concomitant response against the virus toward the tumor. Strategies aimed at facilitating the temporary escape of the virus from the immune response and ultimately redirecting the immune response from the virus to the tumor may propel the development of cancer viroimmunotherapy as a potent and versatile approach to cancer treatment. Here, we examine this issue and other current challenges in cancer virotherapy.

Indexed as

NeoplasmsOncolytic VirotherapyOncolytic VirusesAnimalsHumansAntigen presentationCancer therapyImmunogenicityOncolytic virusesVirotherapy

Identifiers

PMID40515944
PMCPMC13367249

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.