Evidence map›Paper›PMID 40516110›Full record

ArticleChemistry & biodiversity2025

UPLC-ESI-QTOF-MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation.

Ines El Mannoubi, Nuha M Alghamdi, Seham H Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N Abdalla, Majdi Abid, Adel Kadri, Mozaniel Santana de Oliveira

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ines El MannoubiChemistry Department, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Nuha M AlghamdiChemistry Department, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Seham H BashirChemistry Department, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Suada Alsaied MohamedChemistry Department, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Hedia ChaabaneLaboratory of Natural Substances, National Institute of Research and Physico-Chemical Analysis, Ariana, Tunisia.
Ashraf N AbdallaDepartment of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
Majdi AbidDepartment of Chemistry, College of Science, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Adel KadriChemistry Department, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.
Mozaniel Santana de OliveiraPostgraduate Program in Pharmaceutical Sciences (PPGCF), Institute of Health Sciences, Federal University of Pará, Belém, Brazil.ORCID https://orcid.org/0000-0002-4076-2443

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant extracts are emerging as valuable options for food additives and therapeutic treatments. This study evaluated the phytochemical profile, antioxidant activity, and cytotoxicity of aerial parts of Marrubium vulgare L. crude extract (MVCE) and its subfractions. The MVCE (80% ethanol) contained steroids, phenolic compounds, flavonoids, terpenes, and cardiac glycosides, with total phenolic content (TPC) and total flavonoid content (TFC) of 14.96 ± 0.12 mg GAE/g DW and 12.27 ± 0.63 mg RE/g DW, respectively. All MV extracts exhibited potent antioxidant activity against DPPH

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsPlant ExtractsBiphenyl CompoundsCell Line, TumorCell ProliferationCell SurvivalChromatography, High Pressure LiquidDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructurePicratesSpectrometry, Mass, Electrospray IonizationStructure-Activity Relationship1,1-diphenyl-2-picrylhydrazylAntineoplastic Agents, PhytogenicAntioxidantsBiphenyl CompoundsPicratesPlant Extractsantioxidantcytotoxicityin silico studyMarrubium vulgare L.UPLC‐ESI‐QTOF‐MS/MS

Identifiers

PMID40516110
PMCPMC12533807

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.