Evidence map›Paper›PMID 40517318›Full record

ArticleMolecular oncology2025

A DIA-MS-based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients.

Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel and 2 more

Abstract read
In one paragraph

Article in Molecular oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anne ClavreulDépartement de Neurochirurgie, CHU d'Angers, France.ORCID 0000-0002-4477-8282
François GuillonneauNantes Université, Univ Angers, INSERM, CNRS, CRCI2NA, France.
Odile BlanchetCentre de Ressources Biologiques, BB-0033-00038, CHU d'Angers, France.
Hamza LaslaOmics Data Science Unit, Institut de Cancérologie de l'Ouest (ICO), Nantes, France.
Audrey RousseauNantes Université, Univ Angers, INSERM, CNRS, CRCI2NA, France.
Catherine GuetteNantes Université, Univ Angers, INSERM, CNRS, CRCI2NA, France.
Alice BoissardProt'ICO Proteomics Facility, Institut de Cancérologie de l'Ouest (ICO), Angers, France.
Cécile HenryProt'ICO Proteomics Facility, Institut de Cancérologie de l'Ouest (ICO), Angers, France.
Morgan DhondtNantes Université, Univ Angers, INSERM, CNRS, CRCI2NA, France.
Pascal JézéquelNantes Université, Univ Angers, INSERM, CNRS, CRCI2NA, France.
Philippe MeneiDépartement de Neurochirurgie, CHU d'Angers, France.
Jean-Michel LeméeDépartement de Neurochirurgie, CHU d'Angers, France.

Funding

Association en avant la vie
6 · The paper itself

Abstract

No blood-based protein biomarkers are currently available for routine clinical use to determine the prognosis of patients with glioblastoma (GB). We performed data-independent acquisition mass spectrometry (DIA-MS)-based proteomics on 96 presurgical serum samples from patients with GB and 30 serum samples from healthy controls to identify such markers. Among the 622 serum proteins differentially expressed between the GB and control groups, 191 had a |log

Indexed as

Biomarkers, TumorBrain NeoplasmsGlioblastomaMass SpectrometryProteomicsAdultAgedFemaleHumansMaleMiddle AgedPrognosisBiomarkers, Tumorbloodglioblastomaprognosisproteomics

Identifiers

PMID40517318
PMCPMC12420366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.