Evidence map›Paper›PMID 40517524›Full record

ArticlePsychoneuroendocrinology2025

Early life stress, psychiatric conditions, and mitochondrial DNA copy number (mtDNAcn) in medically healthy young adults.

Quincy M Beck, Teresa E Daniels, Leslie A Brick, Stephanie H Parade, Brooke E Hjelm, Bigy Ambat, Daniel Gerke, Marquis P Vawter, Audrey R Tyrka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Quincy M BeckInitiative on Stress, Trauma, and Resilience (STAR), Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA; Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA.
Teresa E DanielsInitiative on Stress, Trauma, and Resilience (STAR), Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA; Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Bradley/Hasbro Children's Research Center, E.P. Bradley Hospital, East Providence, RI, USA. Electronic address: teresa_daniels@brown.edu.
Leslie A BrickInitiative on Stress, Trauma, and Resilience (STAR), Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Stephanie H ParadeInitiative on Stress, Trauma, and Resilience (STAR), Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA; Bradley/Hasbro Children's Research Center, E.P. Bradley Hospital, East Providence, RI, USA.
Brooke E HjelmDepartment of Translational Genomics, Keck School of Medicine of USC, Los Angeles, CA, USA.
Bigy AmbatDepartment of Translational Genomics, Keck School of Medicine of USC, Los Angeles, CA, USA.
Daniel GerkeDepartment of Translational Genomics, Keck School of Medicine of USC, Los Angeles, CA, USA.
Marquis P VawterFunctional Genomics Laboratory, Department of Psychiatry & Human Behavior, University of California, Irvine, CA, USA.
Audrey R TyrkaInitiative on Stress, Trauma, and Resilience (STAR), Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA; Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA.

Funding

Project 3: Isolating food insecurity to understand childhood health outcomes and biological mechanisms of riskP20GM139767 · NIGMS · MIRIAM HOSPITAL · PI KayLoni L. Olson · 2021 to 2026
$14.6M
Mitochondrial Dysfunction In SchizophreniaR01MH085801 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAWTER, MARQUIS PHILIP · 2009 to 2020
$5.0M
Promoting Research Training During Psychiatry ResidencyR25MH101076 · NIMH · BROWN UNIVERSITY · PI AUDREY TYRKA · 2013 to 2026
$2.8M
Early Life Stress: Epigenetic Regulation of Endocrine and Immune PathwaysR01MH101107 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI TYRKA, AUDREY · 2014 to 2018
$2.6M
Research Training in Childhood Stress, Trauma, and ResilienceT32HD101392 · NICHD · MIRIAM HOSPITAL · PI PARADE, STEPHANIE HART, STROUD, LAURA R · 2020 to 2024
$1.7M
Childhood Adversity and Biological Mechanisms of Accelerated AgingR21HD115343 · NICHD · EMMA PENDLETON BRADLEY HOSPITAL · PI PARADE, STEPHANIE HART, TYRKA, AUDREY · 2024 to 2025
$416k
Mechanisms of Accelerated Aging: Stress, Health Behaviors, and the Role of MitochondriaR21AG077332 · NIA · BUTLER HOSPITAL (PROVIDENCE, RI) · PI TYRKA, AUDREY · 2023 to 2024
$413k
NIA NIH HHS R21 AG077332NICHD NIH HHS R21 HD115343NICHD NIH HHS T32 HD101392NIGMS NIH HHS P20 GM139767NIMH NIH HHS R01 MH085801NIMH NIH HHS R01 MH101107NIMH NIH HHS R25 MH101076
6 · The paper itself

Abstract

backgroundEarly life stress (ELS) is a well-established risk factor for psychiatric conditions across the lifespan. A growing body of evidence indicates that alterations to mitochondrial DNA may result from chronic activation of physiological stress responses in ELS and may be associated with psychiatric outcomes. Several studies have found relationships between a number of psychiatric conditions and mtDNA copy number (mtDNAcn), with emerging evidence for a role of early life stress in these associations. This study examined mtDNAcn in physically healthy young adults with and without ELS and a broad range of psychiatric conditions.

methodsParticipants (N = 181; 69.1 % female) included those with ELS and psychiatric conditions (n = 59; ELS+Psych), ELS and no psychiatric conditions (n = 49; ELS-Psych), and with neither ELS nor psychiatric conditions (n = 73; Controls). Standardized interviews and self-reports assessed demographics, stress, and mental health. DNA from PBMCs was used as input for ultra-low coverage whole genome sequencing (ULC-WGS); mtDNAcn was quantified using the fastMitoCalc tool. ANOVAs were used to examine group differences and negative binomial regression models assessed ELS, psychopathology and mtDNAcn relationships with covariates age and sex.

resultsELS+Psych individuals had significantly greater mtDNAcn compared to Control participants (p < .05), even after adjusting for relevant covariates. There was no difference between ELS-Psych individuals and Control participants.

conclusionsIncreased rates of mtDNAcn among individuals with ELS+Psych, but not among those with ELS-Psych, compared to Controls indicates that observable effects of ELS may only occur in the presence of psychiatric symptomatology. Findings and future directions are discussed.

Indexed as

Adverse Childhood ExperiencesDNA Copy Number VariationsDNA, MitochondrialMental DisordersStress, PsychologicalAdolescentAdultFemaleHumansMaleYoung AdultDNA, MitochondrialAllostatic loadChildhood adversityEarly life stressMitochondriaMitochondrial DNA copy numberMtDNAcn

Identifiers

PMID40517524
PMCPMC12764318

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.