Evidence map›Paper›PMID 40518112›Full record

ArticleJournal of advanced research2026

The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.

Zimeng Zhuang, Chunshan Han, Meilian Cai, Mingzhao Li, Shuai Lin, Liujing Chen, Zilu Zhu, Han Zhang, Chenyang Xing, Bing Han and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zimeng ZhuangDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Chunshan HanDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Meilian CaiDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Mingzhao LiDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Shuai LinDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Liujing ChenDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Zilu ZhuDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Han ZhangDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Chenyang XingDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China.
Bing HanDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China. Electronic address: kqbinghan@bjmu.edu.cn.
Ruili YangDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Haidian District, Beijing 100081, PR China; National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Haidian District, Beijing 100081, PR China; Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Haidian District, Beijing 100081, PR China. Electronic address: ruiliyang@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone aging, displays osteoporosis and impaired bone formation, intricately linked to the metabolic alteration of mesenchymal stem cells (MSCs). However, the precise mechanisms underlying this relationship remain unclear.

objectivesTo determine how P2rx7 modulates mitochondrial dynamics during bone aging and osteogenic differentiation of MSCs.

methodsWe established P2rx7

resultsA decreased expression of P2rx7 concurrent with abnormal mitochondrial dynamics was observed in aged bone tissue. To confirm the role of P2rx7 in bone metabolism and aging, we deleted P2rx7 by using P2rx7

conclusionTaken together, our results highlight a role for P2rx7 in regulating mitochondrial dynamics coordinates with ERK pathway, thereby highlighting P2rx7 as a promising target to rejuvenate the tissue aging.

Indexed as

Adenosine TriphosphateAgingBone and BonesMesenchymal Stem CellsMitochondriaReceptors, Purinergic P2X7AnimalsCell DifferentiationMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial DynamicsOsteogenesisAdenosine TriphosphateP2rx7 protein, mouseReceptors, Purinergic P2X7Bone agingERK pathwayMesenchymal stem cellsMitochondrial dynamicsP2X7 receptor

Identifiers

PMID40518112
PMCPMC12957790

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.