Evidence map›Paper›PMID 40518289›Full record

ArticleJournal for immunotherapy of cancer2025

Blockade of colon cancer metastasis via single and double silencing of

Chloé Porcheron, Mailys Le Devehat, Anna Roubtsova, Hadi Bayat, Alexandra Evagelidis, Leila Jafarzadeh, Vatsal Sachan, Nathalie Labrecque, Alexie Fonta Holder, Delia Susan-Resiga and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chloé PorcheronLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0001-8342-3484
Mailys Le DevehatLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0001-9630-5831
Anna RoubtsovaLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0005-5475-8006
Hadi BayatLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-4069-3529
Alexandra EvagelidisLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0007-2331-591X
Leila JafarzadehMaisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.
Vatsal SachanLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-2283-7632
Nathalie LabrecqueInstitut de recherches cliniques de Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-7563-1542
Alexie Fonta HolderLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0006-7208-1278
Delia Susan-ResigaLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-4856-090X
Rachid EssalmaniLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0004-7558-997X
Gabrielle BoudreauMaisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.
Annik PratLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-8007-5277
Rebecca CussedduInstitut de recherches cliniques de Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0000-0693-5585
Jean-François CôtéInstitut de recherches cliniques de Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-7055-2642
Abdel-Majid KhatibInserm, UMR1312, BRIC, Bordeaux Institute of Oncology, University of Bordeaux, Bordeaux, France seidahn@ircm.qc.ca majid.khatib@inserm.fr.ORCID http://orcid.org/0000-0001-6957-0384
Jean-Sébastien DelisleMaisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-1460-7287
Nabil G SeidahLaboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal Biochemical Neuroendocrinology Research Unit, Montreal, Quebec, Canada seidahn@ircm.qc.ca majid.khatib@inserm.fr.ORCID http://orcid.org/0000-0001-6503-9342

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunotherapy approaches based on T cells provided breakthroughs in cancer treatment but could cause many immune-related adverse events, and their efficacy is limited for many cancers with an acquired dysfunction/exhaustion of T cells. The present study presents a novel role in immunity for proprotein convertase subtilisin-kexin 7 (PCSK7), the seventh proprotein convertase of the 9-membered secretory proprotein convertase subtilisin-kexin (PCSK)-family.

methodsWe analyzed cell surface levels of various immune checkpoint proteins in human and mouse cell models in the presence or absence of PCSK7 expression. Injection of mouse colon carcinoma MC38 cells in the spleen of mice lacking either

resultsBioinformatic and cellular studies showed enrichment of PCSK7 mRNA levels in CD8

conclusionsCumulatively, our data provide a

Indexed as

Colonic NeoplasmsProprotein Convertase 9AnimalsCell Line, TumorHumansMiceMice, KnockoutNeoplasm MetastasisPCSK9 protein, humanPcsk9 protein, mouseProprotein Convertase 9Colorectal CancerImmune Checkpoint InhibitorImmunotherapyT cellTumor infiltrating lymphocyte - TIL

Identifiers

PMID40518289
PMCPMC12314818

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.