Evidence map›Paper›PMID 40518812›Full record

Trial reportJournal of Alzheimer's disease : JAD2025

Pimavanserin safety in adult and elderly patients with neuropsychiatric symptoms related to neurodegenerative disease: An open-label extension study.

Wiesław J Cubała, Ana Berrio, Katherine Chi-Burris, Gustavo Alva, Lambros Chrones, Sanjeev Pathak

Abstract readRandomized Controlled TrialClinical Trial, Phase IIIMulticenter Study
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wiesław J CubałaDepartment of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.ORCID 0000-0001-6343-8454
Ana BerrioAcadia Pharmaceuticals Inc., San Diego, CA, USA.ORCID 0009-0007-4310-8264
Katherine Chi-BurrisAcadia Pharmaceuticals Inc., San Diego, CA, USA.
Gustavo AlvaATP Clinical Research, Department of Psychiatry and Neuroscience, University of California at Riverside, Riverside, CA, USA.ORCID 0000-0001-9742-398X
Lambros ChronesAcadia Pharmaceuticals Inc., Princeton, NJ, USA.ORCID 0000-0001-7822-9364
Sanjeev PathakAcadia Pharmaceuticals Inc., Princeton, NJ, USA.ORCID 0000-0001-5842-690X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundAn 8-week, phase 3b, randomized, placebo-controlled trial demonstrated that pimavanserin, a selective 5HT

Indexed as

Neurodegenerative DiseasesPiperidinesUreaAdultAgedAged, 80 and overDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment OutcomepimavanserinPiperidinesUreaAlzheimer's diseaseantipsychotic agentsfrail elderlyneurodegenerative diseasessafety

Identifiers

PMID40518812
PMCPMC12464353

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.