Evidence map›Paper›PMID 40518921›Full record

ArticleInnate immunity

Mutation within the transmembrane domain of oxidized low-density lipoprotein receptor 1 influences oxidized low-density lipoprotein-induced signal transduction.

Zhen Ma, Ran Xu, Jing Lu, Xiong Huang, Hao Jia, Zhiwen Ding, Jie Yuan, Yunzeng Zou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhen MaInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Ran XuShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai, China.
Jing LuInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Xiong HuangDepartment of General Surgery, Shanghai Eighth People's Hospital, Shanghai, China.
Hao JiaDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China.
Zhiwen DingShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai, China.
Jie YuanShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai, China.
Yunzeng ZouInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.ORCID 0009-0005-8307-6725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo investigate the important active sites within the NTFs to affect the

Indexed as

Foam CellsLipoproteins, LDLMonocytesScavenger Receptors, Class EAnimalsChlorocebus aethiopsCOS CellsHumansMutationProtein DomainsSignal TransductionTHP-1 CellsLipoproteins, LDLOLR1 protein, humanoxidized low density lipoproteinScavenger Receptors, Class EERK1/2intracellular signal transductionOxidized low-density lipoprotein receptor 1site mutationtransmembrane domain

Identifiers

PMID40518921
PMCPMC12174723

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.