Evidence map›Paper›PMID 40518969›Full record

ArticleEmerging microbes & infections2025

The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal disease.

Covadonga Pérez-García, Aída González-Díaz, Mirian Domenech, Mirella Llamosí, Aída Úbeda, Juan Carlos Sanz, Ernesto García, Carmen Ardanuy, Julio Sempere, Jose Yuste

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Antibacterial and Antibiofilm Activity ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Severe invasive pneumococcal disease beyond current vaccination recommendations: implications for higher-valency vaccines.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. [Pneumococcal meningitis in a tertiary care hospital: clinical characteristics, serotype distribution, and vaccination status].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Covadonga Pérez-GarcíaSpanish Pneumococcal Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-5295-6480
Aída González-DíazMicrobiology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
Mirian DomenechSpanish Pneumococcal Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-0942-8180
Mirella LlamosíSpanish Pneumococcal Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-4369-9558
Aída ÚbedaSpanish Pneumococcal Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Juan Carlos SanzRegional Public Health Laboratory, Comunidad de Madrid, Madrid, Spain.
Ernesto GarcíaCentro de Investigaciones Biológicas Margarita Salas-CSIC, Madrid, Spain.
Carmen ArdanuyMicrobiology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
Julio SempereSpanish Pneumococcal Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0001-9340-6867
Jose YusteSpanish Pneumococcal Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0001-7996-0837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite conjugate vaccine introduction to prevent invasive pneumococcal disease (IPD), serotype replacement by non-vaccine serotypes is a constant concern. In this study, we elucidate the rise of serotype 8 causing IPD in Spain. We evaluated isolates received during the period 2008-2023 including whole genome sequencing characterization and host-pathogen interaction studies. Serotype 8 has emerged as one of the most prevalent serotypes causing IPD in both children and adults. CC53/GPSC3 carrying

Indexed as

Bacterial CapsulesMutationOperonPneumococcal InfectionsStreptococcus pneumoniaeAdultAnimalsBacterial AdhesionBacterial ProteinsBiofilmsChildFemaleHost-Pathogen InteractionsHumansMiceSerogroupBacterial ProteinsGPSC3GPSC9GPSC98IPDmucoid coloniesPspcserotype 8Wcha

Identifiers

PMID40518969
PMCPMC12231264

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.