Evidence map›Paper›PMID 40519270›Full record

ReviewFrontiers in cell and developmental biology2025

Biomedical applications of organoids derived from the digestive system.

Zhensheng Xu, Zhongwen Lei, Qiuhua Cheng, Yuanhui Gao, Yang Xiang

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhensheng Xu *Department of Oncologic Chemotheraphy, Haikou Affiliated Hospital of Central South University Xiangya School of Medcine, Haikou, China.
Zhongwen Lei *Department of Hepatobiliary Surgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medcine, Haikou, China.
Qiuhua ChengDepartment of Hepatobiliary Surgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medcine, Haikou, China.
Yuanhui GaoCentral Laboratory, Haikou Affiliated Hospital of Central South University Xiangya School of Medcine, Haikou, China.
Yang XiangDepartment of Hepatobiliary Surgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medcine, Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global incidence of digestive system diseases is increasing, posing a significant public health challenge and driving an escalating demand for research into the mechanisms underlying their onset and progression. Traditional cell models and xenotransplantation animal models have been widely used to simulate human digestive diseases, thereby enhancing our understanding of disease occurrence, progression, and drug resistance. However, these models fail to fully replicate the complex cellular microenvironment and spatial structure, and are further limited by individual and species differences. Organoid technology, as an emerging

Indexed as

digestive systemdrug screeningmechanisms of growthmodeling of diseaseorganoidsregenerative medicine

Identifiers

PMID40519270
PMCPMC12162665

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.