Evidence map›Paper›PMID 40519547›Full record

ArticleFrontiers in pediatrics2025

Clinical relevance of bacterial and/or viral coinfection in acute bronchiolitis in an Italian neonatal unit during the 2021-2023 seasons.

Venere Cortazzo, Marilena Agosta, Domenico Umberto De Rose, Valeria Fox, Velia Chiara Di Maio, Gianluca Vrenna, Martina Rossitto, Barbara Lucignano, Stefania Ranno, Annamaria Sisto and 6 more

Abstract read
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Venere Cortazzo *Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Marilena Agosta *Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Domenico Umberto De RoseNeonatal Intensive Care Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Valeria FoxMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Velia Chiara Di MaioMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Gianluca VrennaMultimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Martina RossittoMultimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Barbara LucignanoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Stefania RannoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Annamaria SistoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Cristina RussoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Annabella BragugliaNeonatal Sub-Intensive Care Unit and Follow-up, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Maria Paola RonchettiNeonatal Intensive Care Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Andrea DottaNeonatal Intensive Care Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Carlo Federico PernoMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Paola BernaschiMicrobiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute bronchiolitis is a leading cause of hospitalization in young children worldwide, and literature reports conflicting data regarding the role of coinfections. Objective: To evaluate the possible clinical relevance of bacterial and/or viral respiratory coinfection in a cohort of newborns/infants hospitalized for bronchiolitis. Methods: Neonates and infants younger than three months admitted to neonatal units from October 2021 to March 2023 because of acute bronchiolitis were included in this retrospective study. Analyses were performed with Stata 11.1 ( Results: In a cohort of 240 patients, respiratory coinfection was associated with a longer hospital stay ( Conclusion: Coinfections increased the clinical severity of bronchiolitis more than simple viral mono-infection in our cohort, contributing to a longer hospital stay and the need for invasive mechanical ventilation.

Indexed as

bronchiolitiscoinfectionsinfantsnewbornsrespiratory infectionsrhinovirusRSVviral monoinfection

Identifiers

PMID40519547
PMCPMC12162940

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.