Evidence map›Paper›PMID 40519638›Full record

ArticleBiological psychiatry global open science2025

Peripheral MicroRNA Signatures in Adolescent Depression.

Alice Morgunova, Nicholas O'Toole, Fatme Abboud, Saché Coury, Gary Gang Chen, Maxime Teixeira, Eamon Fitzgerald, Gustavo Turecki, Anthony J Gifuni, Ian H Gotlib and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alice MorgunovaIntegrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
Nicholas O'TooleDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Fatme AbboudDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Saché CouryDepartment of Psychology, Stanford University, Stanford, California.
Gary Gang ChenDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Maxime TeixeiraIntegrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
Eamon FitzgeraldDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Anthony J GifuniDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, California.
Corina NagyDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Michael J MeaneyDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Tiffany C HoDepartment of Psychology, Stanford University, Stanford, California.
Cecilia FloresDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.

Funding

Amphetamine in adolescence disrupts frontal cortex developmentR01DA037911 · NIDA · MCGILL UNIVERSITY · PI FLORES, CECILIA · 2015 to 2024
$2.5M
NIDA NIH HHS R01 DA037911
6 · The paper itself

Abstract

Background: Adolescent depression is linked to enduring maladaptive outcomes, chronic severity of symptoms, and poor treatment response. Identifying epigenetic signatures of adolescent depression is urgently needed to improve early prevention and intervention strategies. MicroRNAs (miRNAs) are epigenetic regulators of adolescent neurodevelopmental processes, but their role as markers and mediators of adolescent depression is unknown. Methods: Here, we examined miRNA profiles from dried blood spot samples of male and female adolescents with clinical depression and psychiatrically healthy male and female adolescents ( Results: We identified 9 differentially expressed (DE) miRNAs (adjusted Conclusions: These findings lay the groundwork for identifying adolescent peripheral miRNA markers that reflect neurodevelopmental pathways that shape lifelong psychopathology risk.

Indexed as

AdolescenceDepressionDevelopmentDried blood spotsMental healthMicroRNA

Identifiers

PMID40519638
PMCPMC12166373

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.