ReviewBiochemistry and biophysics reports2025
Role of oxidative stress in prediabetes development.
Review in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Article
- New sesquiterpenoids fromRSC advances · 2026Article
- Anthocyanin-Rich Extracts from Bilberries and Blackcurrants in Human Health: A Narrative Review of Their Anti-Inflammatory and Antioxidant Effects.Journal of clinical medicine · 2026Review
- Investigating the relationship between monocyte to high-density lipoprotein cholesterol ratio and carotid artery plaque in cerebral infarction patients under different blood pressure and glucose metabolic conditions.Lipids in health and disease · 2026Article
- Anti-Diabetic Potential of Corn (Preventive nutrition and food science · 2026Review
- Arginyl-Fructosyl-Glucose Derived from Korean Red Ginseng Attenuates Methylglyoxal-Induced Insulin Resistance in HepG2 Cells.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Association between estimated pulse wave velocity and impaired fasting glucose: a multicenter retrospective cohort study in China.Frontiers in endocrinology · 2026Article
- Selective bioactive effects ofFrontiers in pharmacology · 2026Article
- Evaluation of Serum Antioxidant Activity in Type 2 Diabetes and Prediabetes: Links with Nutritional and Anthropometric Factors-Preliminary Studies.Current issues in molecular biology · 2025Article
- Efficacy ofMetabolism open · 2025Review
- Redox Homeostasis in Metabolic Syndrome and Type II Diabetes: Role of Skeletal Muscle and Impact of Gold-Standard Treatments.International journal of molecular sciences · 2025Review
- Article
- Adenosine Monophosphate-Activated Protein Kinase Activation and Mammalian Target of Rapamycin Complex 1 Inhibition: A Mechanistic Rationale for Anti-Aging Therapy in Type 2 Diabetes.Journal of clinical medicine research · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
An imbalance between the generation of reactive oxygen species (ROS) and antioxidant defense systems is known as oxidative stress, and it is a major factor in diseases like atherosclerosis, vascular inflammation, endothelial dysfunction, and others that are largely caused by elevated oxidative stress. Interestingly, oxidative stress has also been implicated in the progression of prediabetes to type 2 diabetes (T2DM). Prediabetes, characterized by increased blood glucose levels than the diabetes threshold, impacts a substantial portion of the global population. In India alone, the estimated prevalence of prediabetes by 2023 is approximately 15.3 %. Hyperglycaemia, a hallmark of prediabetes, can promote vascular dysfunction by increasing ROS formation and upregulating chronic inflammatory markers. Additionally, oxidative stress contributes to insulin resistance and impaired beta cell function. Various risk factors of oxidative stress are associated with prediabetes development. This review focuses on ROS's role in prediabetes pathogenesis and its risk factors increasing the effect of oxidative stress. Various ROS scavengers were used as oxidative stress indicators, and ROS scavenging has a deleterious impact on disease progression. Lack of study has reported on role of oxidative stress in prediabetes development and this will be the first review covers pathogenesis and impact of oxidative stress biomarker in prediabetes. This review comprises managing the risk factors of oxidative stress would pave the way for the management of prediabetes progression to T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.