ArticleFrontiers in immunology2025
Association between pan-immune-inflammation value and Serum Klotho levels: a cross-sectional analysis of renal function mediation.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- α-Klotho as a central integrative signalling hub in cognitive function and neuroprotection in neurodegenerative diseases.Metabolic brain disease · 2026Review
- HALP score inOpen medicine (Warsaw, Poland) · 2025Article
- Cross-sectional and longitudinal associations between pan-immune-inflammation value and serum uric acid.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Klotho has emerged as a promising biomarker of aging processes. Although inflammation is known to modulate Klotho expression, the relationship between Pan-Immune-Inflammation Value (PIV) and serum Klotho levels has not been investigated. This study aimed to examine the association between PIV and serum Klotho levels while exploring the potential mediating effects of renal function parameters. Methods: A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2016. A total of 13,406 participants were included. Multiple linear regression models were used to evaluate the association between PIV and Klotho levels. Boruta feature selection method was used to identify variables included in the multivariable models. Smooth curve fitting was performed to examine potential non-linear relationships and threshold effect analysis was conducted using a two-piecewise linear regression model. Mediation analysis was conducted to assess the role of renal function indicators. Stratified analyses were performed to identify potential effect modifiers. Results: After fully adjusting for potential confounders, PIV showed a significant inverse association with serum Klotho levels (β=-0.11, 95%CI: -0.15, -0.07, Conclusion: Elevated PIV was found to be significantly associated with lower klotho levels, with renal function indicators playing a mediating role.
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Registered trials
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